noble_2001

17/09/07

Received fixed file from Penny Noble:

"In this group we have used several models, including Noble98, to run some tests and it was noticed that the model never reached steady state. The reason for this was that INaCads had not been added to either of the calcium (Cai or Cads) ODEs. Logically and physiologically we would like to fix this issue by adding INaCads to dCads/dt. However this causes instability in the model. Hence in order to fix the problem of charge conservation, but to maintain the output of the model as similar as possible to the original and published Noble98, we have added INaCads to the dCai/dt equation. Note that additional work has been done in our group, by Anna Sher in collaboration with Denis and Penny Noble, to look at INaCa in the dyadic space and at some stage we plan to produce an update of our guinea-pig ventricular cell model to incorporate this modelling work. Same ‘fix’ applied to the Noble 2001 model."

This file will be uploaded as version 06.