Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

The metabolism of the human erythrocyte is extensively characterised. When combined with its relative metabolic simplicity, it's easy to understand why it has been the subject of several mathematical models. Although these models have identified many important features of metabolic control, none have focused on the regulation of 2,3-bisphosphoglycerate (2,3-BPG) concentration and turnover. By modulating the oxygen affinity of haemoglobin, 2,3-BPG plays an essential role in the regulation of blood oxygen transport and delivery. Therefore understanding the regulation of 2,3-BPG is important for understanding blood oxygen transport.

In 1999, Peter J. Mulquiney, William A. Bubb and Philip W. Kuchel published a series of three papers that present a detailed mathematical model of erythrocyte metabolism. Specifically, they concentrate on 2,3-BPG metabolism. The model is restricted to the core metabolic pathways; glycolysis, the 2,3-BPG shunt and the pentose phoshate pathway (see below). This reaction scheme is broken down into several submodel components (see below).

The complete original paper references are cited below:

Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: in vivo kinetic characterisation of 2,3-bisphosphoglycerate synthase/phosphatase using ¹³C and ³¹P NMR, Peter J. Mulquiney, William A. Bubb and Philip W. Kuchel, 1999, Biochem. J. , 342, 567-580. (Full text (HTML) and PDF versions of the article are available on the Biochemical Journal website.) Pubmed ID: 10477268

Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement, Peter J. Mulquiney and Philip W. Kuchel, 1999, Biochem. J. , 342, 581-596. (Full text (HTML) and PDF versions of the article are available on the Biochemical Journal website.) Pubmed ID: 10477269

Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: computer simulation and Metabolic Control Analysis, Peter J. Mulquiney and Philip W. Kuchel, 1999, Biochem. J. , 342, 597-604. (Full text (HTML) and PDF versions of the article are available on the Biochemical Journal website.) Pubmed ID: 10477270

The raw CellML descriptions of the submodels of erythrocyte metabolism can be downloaded in various formats as described in . For an example of a more complete documentation of another real reaction pathway, see The Bhalla Iyengar EGF Pathway Model, 1999.

Reaction Scheme of the major metabolic pathways in the human erythrocyte: glycolysis, the 2,3-BPG shunt and the pentose phosphate pathway.

Minimal submodels of metabolism in the human erythrocyte.

• mulquiney_bubb_kuchel_1999_version01.cellml
• mulquiney_bubb_kuchel_1999_version02.cellml