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Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy

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Programming Language C

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Model is underconstrained. The following variables couldn't be computed:

• delta_Active_G_protein_rxn3

• delta_Inactive_G_protein_rxn3

• delta_Inactive_receptor_rxn4

• delta_Ligand_rxn4

• delta_Inactive_receptor_ligand_complex_rxn4

• delta_Active_receptor_rxn5

• delta_Ligand_rxn5

• delta_Active_receptor_ligand_complex_rxn5

• delta_Inactive_receptor_rxn6

• delta_Active_receptor_rxn6

• delta_Inactive_receptor_ligand_complex_rxn7

• delta_Active_receptor_ligand_complex_rxn7

• delta_Inactive_G_protein_rxn8

• delta_Active_G_protein_rxn8

• delta_Ligand_rxn0

• delta_Desensitised_receptor_rxn0

• delta_Desensitised_receptor_ligand_complex_rxn0

• delta_Active_receptor_ligand_complex_rxn1

• delta_Desensitised_receptor_ligand_complex_rxn1

• delta_Inactive_G_protein_rxn2

• delta_Active_G_protein_rxn2