Model Documentation

Model Status

This CellML model is the model which was used to produce the original results in the paper, and therefore it is known to be completely accurate.

Model Structure

The model structure illustrates a modular version of the cardiac myocyte IP3 production system as developed in the paper:

Modeling hypertrophic IP3 transients in the cardiac myocyte, Michael Cooling, Peter Hunter and Edmund J. Crampin, 2007, Biophysical Journal , 93, 3421-3433. (Full text and PDF versions of the article are available to journal subscribers on the Biophysical Journal website.) PubMed ID: 17693463

The process of how this model was modularised into functional and messenger components is described in detail in the paper:

Modelling biological modularity with CellML, M.T. Cooling, P. Hunter, and E.J. Crampin, 2008, IET Systems Biology , 2(2), 73-79. (Currently In Press).

A schematic diagram of the CellML model.

Related models: Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte (ref to: http://www.cellml.org/models/cooling_hunter_crampin_2007_version01)

This is a link to Modeling Biological Modularity with CellML. Please get the model code here.