Model Documentation

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

One of the central goals in the study of calcium signalling is to understand the basis of [Ca²⁺] dynamics. This is complicated by the fact that Ca²⁺ is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca²⁺ transport system and the rate of Ca²⁺ transport between these compartments can exhibit a complex non-linear dependence on free [Ca²⁺].

In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca²⁺ transport contributes to the redistribution of intracellular Ca²⁺ during and after depolarisation-evoked Ca²⁺ entry in sympathetic neurons. The total Ca²⁺ flux during the recovery phase following membrane depolarisation was divided into three components (see the figure below): one representing net Ca²⁺ extrusion across the plasma membrane (J_extru), one representing mitochondrial Ca²⁺ uptake via the uniporter (J_uni) and one representing mitochondrial Ca²⁺ release via the Na⁺/Ca²⁺ exchanger (J_NaCa). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .

The complete original paper reference is cited below:

Quantitative Analysis of Mitochondrial Ca²⁺ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca²⁺] Elevations , Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000, The Journal Of General Physiology , 115, 371-388. (Full text and PDF versions of the article are available for Journal Members on the JGP website.) PubMed ID: 10694264

Schematic of the model indicating Ca2+ compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca2+ ion movement between the compartments.