Component: environment

Component: Cln2

$d Cln2 d time = mass (ks_n2 + ks_n2_SBF) − kd_n2 Cln2$

Component: Clb2_T

$d Clb2_T d time = mass (ks_b2 + ks_b2_Mcm1) − Vd_b2 Clb2_T Vd_b2 = kd_b2 (Hct1_T − Hct1) + kd_b2_Hct1 + kd_b2__Cdc20 Hct1_T = (Vd_b2 − kd_b2_Hct1 + kd_b2__Cdc20) / kd_b2 + Hct1$

Component: Clb2

$Clb2 = Clb2_T − Clb2_Sic1$

Component: Clb5

$Clb5 = Clb5_T − Clb5_Sic1$

Component: Sic1

$Sic1 = Sic1_T − Clb2_Sic1 + Clb5_Sic1$

Component: Clb5_T

$d Clb5_T d time = mass (ks_b5 + ks_b5_MBF) − Vd_b5 Clb5_T Vd_b5 = kd_b5 + kd_b5_Cdc20$

Component: Bck2

$Bck2 = Bck2_0 mass$

Component: Cln3

$Cln3 = Cln3_max Dn3 mass / (Jn3 + Dn3 mass)$

Component: Sic1_T

$d Sic1_T d time = ks_c1 + ks_c1_Swi5 − Sic1_T (kd1_c1 + Vd2_c1 / (Jd2_c1 + Sic1_T))$

Component: Clb2_Sic1

$d Clb2_Sic1 d time = kas_b2 Clb2_Sic1 − Clb2_Sic1 (kdi_b2 + Vd_b2 + kd1_c1 + Vd2_c1 / (Jd2_c1 + Sic1_T))$

Component: Clb5_Sic1

$d Clb5_Sic1 d time = kas_b5 Clb5_Sic1 − Clb5_Sic1 (kdi_b5 + Vd_b5 + kd1_c1 + Vd2_c1 / (Jd2_c1 + Sic1_T))$

Component: Vd2_c1

$Vd2_c1 = kd2_c1 (epsilonc1_n3 Cln3 + epsilonc1_k2 Bck2 + Cln2 + epsilonc1_b5 Clb5 + epsilonc1_b2 Clb2)$

Component: Cdc20_T

$d Cdc20_T d time = ks_20 + ks_20_Clb2 − kd_20 Cdc20_T$

Component: Cdc20

$d Cdc20 d time = ka_20 (Cdc20_T − Cdc20) − Cdc20 (Vi_20 + kd_20) Vi_20 = {ki_20 if (time > END_M + 12.0) ∧ (time < START_S) ki_20_if (time > START_S) ∧ (time < END_M)$

Component: Hct1

$d Hct1 d time = (ka_t1 + ka_t1_Cdc20) (Hct1_T − Hct1) / (Ja_t1 + Hct1_T − Hct1) − Vi_t1 Hct1 / (Ji_t1 + Hct1) Vi_t1 = ki_t1 + ki_t1_Cln3 + epsiloni_t1_n2 Cln2 + epsiloni_t1_b5 Clb5 + epsiloni_t1_b2 Clb2$

Component: mass

$d mass d time = mu mass$

Component: ORI

$d ORI d time = ks_ori Clb5 + epsilonori_b2 Clb2 + kd_ori ORI$

Component: BUD

$d BUD d time = ks_bud Cln2 + Cln3 + epsilonbud_b5 Clb5 + kd_bud BUD$

Component: SPN

$d SPN d time = Clb2 / (J_spn + Clb2) − kd_spn SPN$

Component: SBF

$SBF = 2.0 Va_sbf Ji_sbf / (ki_sbf + ki_sbf_Clb2 + Va_sbf Ji_sbf + (ki_sbf + ki_sbf_Clb2) Ja_sbf − Va_sbf + ((ki_sbf + ki_sbf_Clb2 + Va_sbf Ji_sbf + (ki_sbf + ki_sbf_Clb2) Ja_sbf − Va_sbf) 2.0 − 4.0 (ki_sbf + ki_sbf_Clb2 + Va_sbf Ji_sbf + (ki_sbf + ki_sbf_Clb2) Ja_sbf − Va_sbf − Va_sbf) Va_sbf Ji_sbf) 0.5) Va_sbf = ka_sbf Cln2 + epsilonsbf_n3 (Cln3 + Bck2) + epsilonsbf_b5 Clb5$

Component: MBF

$MBF = SBF$

Component: Mcm1

$Mcm1 = 2.0 ka_mcm Clb2 Ji_mcm / (ki_mcm + ka_mcm Clb2 Ji_mcm + ki_mcm Ja_mcm − ka_mcm Clb2 + ((ki_mcm + ka_mcm Clb2 Ji_mcm + ki_mcm Ja_mcm − ka_mcm Clb2) 2.0 − 4.0 (ki_mcm − ka_mcm Clb2) ka_mcm Clb2 Ji_mcm) 0.5)$

Component: Swi5

$Swi5 = 2.0 ka_swi Cdc20 Ji_swi / (ki_swi + ki_swi_Clb2 + ka_swi Cdc20 Ji_swi + (ki_swi + ki_swi_Clb2) Ja_swi − ka_swi Cdc20 + ((ki_swi + ki_swi_Clb2 + ka_swi Cdc20 Ji_swi + (ki_swi + ki_swi_Clb2) Ja_swi − ka_swi Cdc20) 2.0 − 4.0 (ki_swi + ki_swi_Clb2 − ka_swi Clb2) ka_swi Cdc20 Ji_swi) 0.5)$