A Computer Model for the Action Potential of Mouse Ventricular Myocytes

Generated code

• The required array sizes are:
  • VARIABLES[113]
  • CONSTANTS[66]
  • BOUND[1]
  • RATES[41]
• The following variables are defined:
  • Variable gamma(VARIABLES[41]; recomputed after rate changes)
  • Variable Kpcf(VARIABLES[42]; recomputed after rate changes)
  • Variable Kpcb(CONSTANTS[0])
  • Variable Kpc_max(CONSTANTS[1])
  • Variable Kpc_half(CONSTANTS[2])
  • Variable i_pCa(VARIABLES[43]; recomputed after rate changes)
  • Variable i_pCa_max(CONSTANTS[3])
  • Variable Km_pCa(CONSTANTS[4])
  • Variable i_NaCa(VARIABLES[44]; recomputed after rate changes)
  • Variable k_NaCa(CONSTANTS[5])
  • Variable K_mNa(CONSTANTS[6])
  • Variable K_mCa(CONSTANTS[7])
  • Variable k_sat(CONSTANTS[8])
  • Variable eta(CONSTANTS[9])
  • Variable i_Cab(VARIABLES[45]; recomputed after rate changes)
  • Variable g_Cab(CONSTANTS[10])
  • Variable E_CaN(VARIABLES[46]; recomputed after rate changes)
  • Variable P_C2(RATES[0] and VARIABLES[0])
  • Variable k_plus_a(CONSTANTS[11])
  • Variable k_minus_a(CONSTANTS[12])
  • Variable k_plus_b(CONSTANTS[13])
  • Variable k_minus_b(CONSTANTS[14])
  • Variable k_plus_c(CONSTANTS[15])
  • Variable k_minus_c(CONSTANTS[16])
  • Variable m(CONSTANTS[17])
  • Variable n(CONSTANTS[18])
  • Variable i_CaL(VARIABLES[47]; recomputed after rate changes)
  • Variable i_CaL_max(CONSTANTS[19])
  • Variable E_CaL(CONSTANTS[20])
  • Variable g_CaL(CONSTANTS[21])
  • Variable O(RATES[1] and VARIABLES[1])
  • Variable C1(VARIABLES[48]; recomputed after rate changes)
  • Variable C2(RATES[2] and VARIABLES[2])
  • Variable C3(RATES[3] and VARIABLES[3])
  • Variable C4(RATES[4] and VARIABLES[4])
  • Variable I1(RATES[5] and VARIABLES[5])
  • Variable I2(RATES[6] and VARIABLES[6])
  • Variable I3(RATES[7] and VARIABLES[7])
  • Variable alpha(VARIABLES[49]; recomputed after rate changes)
  • Variable beta(VARIABLES[50]; recomputed after rate changes)
  • Variable i_Kto_f(VARIABLES[51]; recomputed after rate changes)
  • Variable E_K(VARIABLES[52]; recomputed after rate changes)
  • Variable g_Kto_f(CONSTANTS[22])
  • Variable ato_f(RATES[8] and VARIABLES[8])
  • Variable ito_f(RATES[9] and VARIABLES[9])
  • Variable alpha_a(VARIABLES[53]; recomputed after rate changes)
  • Variable beta_a(VARIABLES[54]; recomputed after rate changes)
  • Variable alpha_i(VARIABLES[55]; recomputed after rate changes)
  • Variable beta_i(VARIABLES[56]; recomputed after rate changes)
  • Variable i_Kto_s(VARIABLES[57]; recomputed after rate changes)
  • Variable ass(VARIABLES[58]; recomputed after rate changes)
  • Variable iss(VARIABLES[59]; recomputed after rate changes)
  • Variable g_Kto_s(CONSTANTS[23])
  • Variable ato_s(RATES[10] and VARIABLES[10])
  • Variable ito_s(RATES[11] and VARIABLES[11])
  • Variable tau_ta_s(VARIABLES[60]; recomputed after rate changes)
  • Variable tau_ti_s(VARIABLES[61]; recomputed after rate changes)
  • Variable i_K1(VARIABLES[62]; recomputed after rate changes)
  • Variable i_Ks(VARIABLES[63]; recomputed after rate changes)
  • Variable g_Ks(CONSTANTS[24])
  • Variable nKs(RATES[12] and VARIABLES[12])
  • Variable alpha_n(VARIABLES[64]; recomputed after rate changes)
  • Variable beta_n(VARIABLES[65]; recomputed after rate changes)
  • Variable i_Kur(VARIABLES[66]; recomputed after rate changes)
  • Variable g_Kur(CONSTANTS[25])
  • Variable J_trpn(VARIABLES[67]; recomputed after rate changes)
  • Variable J_xfer(VARIABLES[68]; recomputed after rate changes)
  • Variable k_plus_htrpn(CONSTANTS[26])
  • Variable k_minus_htrpn(CONSTANTS[27])
  • Variable k_plus_ltrpn(CONSTANTS[28])
  • Variable k_minus_ltrpn(CONSTANTS[29])
  • Variable P_RyR(RATES[13] and VARIABLES[13])
  • Variable v1(CONSTANTS[30])
  • Variable tau_tr(CONSTANTS[31])
  • Variable v2(CONSTANTS[32])
  • Variable tau_xfer(CONSTANTS[33])
  • Variable v3(CONSTANTS[34])
  • Variable Km_up(CONSTANTS[35])
  • Variable Cai(RATES[14] and VARIABLES[14])
  • Variable Cass(RATES[15] and VARIABLES[15])
  • Variable CaJSR(RATES[16] and VARIABLES[16])
  • Variable CaNSR(RATES[17] and VARIABLES[17])
  • Variable Bi(VARIABLES[69]; recomputed after rate changes)
  • Variable Bss(VARIABLES[70]; recomputed after rate changes)
  • Variable BJSR(VARIABLES[71]; recomputed after rate changes)
  • Variable CMDN_tot(CONSTANTS[36])
  • Variable CSQN_tot(CONSTANTS[37])
  • Variable Km_CMDN(CONSTANTS[38])
  • Variable Km_CSQN(CONSTANTS[39])
  • Variable J_leak(VARIABLES[72]; recomputed after rate changes)
  • Variable J_rel(VARIABLES[73]; recomputed after rate changes)
  • Variable J_up(VARIABLES[74]; recomputed after rate changes)
  • Variable J_tr(VARIABLES[75]; recomputed after rate changes)
  • Variable time(BOUND[0])
  • Variable V(RATES[18] and VARIABLES[18])
  • Variable Cm(CONSTANTS[40])
  • Variable Vmyo(CONSTANTS[41])
  • Variable VJSR(CONSTANTS[42])
  • Variable VNSR(CONSTANTS[43])
  • Variable Vss(CONSTANTS[44])
  • Variable Acap(CONSTANTS[45])
  • Variable Ko(CONSTANTS[46])
  • Variable Nao(CONSTANTS[47])
  • Variable Cao(CONSTANTS[48])
  • Variable R(CONSTANTS[49])
  • Variable Nai(RATES[19] and VARIABLES[19])
  • Variable i_Na(VARIABLES[76]; recomputed after rate changes)
  • Variable E_Na(VARIABLES[77]; recomputed after rate changes)
  • Variable g_Na(CONSTANTS[50])
  • Variable O_Na(RATES[20] and VARIABLES[20])
  • Variable C_Na1(RATES[21] and VARIABLES[21])
  • Variable C_Na2(RATES[22] and VARIABLES[22])
  • Variable C_Na3(VARIABLES[78]; recomputed after rate changes)
  • Variable I1_Na(RATES[23] and VARIABLES[23])
  • Variable I2_Na(RATES[24] and VARIABLES[24])
  • Variable IF_Na(RATES[25] and VARIABLES[25])
  • Variable IC_Na2(RATES[26] and VARIABLES[26])
  • Variable IC_Na3(RATES[27] and VARIABLES[27])
  • Variable alpha_Na11(VARIABLES[79]; recomputed after rate changes)
  • Variable beta_Na11(VARIABLES[80]; recomputed after rate changes)
  • Variable alpha_Na12(VARIABLES[81]; recomputed after rate changes)
  • Variable beta_Na12(VARIABLES[82]; recomputed after rate changes)
  • Variable alpha_Na13(VARIABLES[83]; recomputed after rate changes)
  • Variable beta_Na13(VARIABLES[84]; recomputed after rate changes)
  • Variable alpha_Na3(VARIABLES[85]; recomputed after rate changes)
  • Variable beta_Na3(VARIABLES[86]; recomputed after rate changes)
  • Variable alpha_Na2(VARIABLES[87]; recomputed after rate changes)
  • Variable beta_Na2(VARIABLES[88]; recomputed after rate changes)
  • Variable alpha_Na4(VARIABLES[89]; recomputed after rate changes)
  • Variable beta_Na4(VARIABLES[90]; recomputed after rate changes)
  • Variable alpha_Na5(VARIABLES[91]; recomputed after rate changes)
  • Variable beta_Na5(VARIABLES[92]; recomputed after rate changes)
  • Variable i_Nab(VARIABLES[93]; recomputed after rate changes)
  • Variable g_Nab(CONSTANTS[51])
  • Variable Ki(RATES[28] and VARIABLES[28])
  • Variable i_ClCa(VARIABLES[94]; recomputed after rate changes)
  • Variable g_ClCa(CONSTANTS[52])
  • Variable O_ClCa(VARIABLES[95]; recomputed after rate changes)
  • Variable E_Cl(CONSTANTS[53])
  • Variable Km_Cl(CONSTANTS[54])
  • Variable T(CONSTANTS[55])
  • Variable F(CONSTANTS[56])
  • Variable i_stim(VARIABLES[96]; recomputed after rate changes)
  • Variable LTRPN_tot(CONSTANTS[57])
  • Variable HTRPN_tot(CONSTANTS[58])
  • Variable LTRPN_Ca(RATES[29] and VARIABLES[29])
  • Variable HTRPN_Ca(RATES[30] and VARIABLES[30])
  • Variable P_O1(RATES[31] and VARIABLES[31])
  • Variable P_O2(RATES[32] and VARIABLES[32])
  • Variable P_C1(VARIABLES[97]; recomputed after rate changes)
  • Variable aur(RATES[33] and VARIABLES[33])
  • Variable iur(RATES[34] and VARIABLES[34])
  • Variable tau_aur(VARIABLES[98]; recomputed after rate changes)
  • Variable tau_iur(VARIABLES[99]; recomputed after rate changes)
  • Variable i_Kss(VARIABLES[100]; recomputed after rate changes)
  • Variable g_Kss(CONSTANTS[59])
  • Variable aKss(RATES[35] and VARIABLES[35])
  • Variable iKss(RATES[36] and VARIABLES[36])
  • Variable tau_Kss(VARIABLES[101]; recomputed after rate changes)
  • Variable i_Kr(VARIABLES[102]; recomputed after rate changes)
  • Variable g_Kr(CONSTANTS[60])
  • Variable O_K(RATES[37] and VARIABLES[37])
  • Variable C_K1(RATES[38] and VARIABLES[38])
  • Variable C_K2(RATES[39] and VARIABLES[39])
  • Variable C_K0(VARIABLES[103]; recomputed after rate changes)
  • Variable I_K(RATES[40] and VARIABLES[40])
  • Variable alpha_a0(VARIABLES[104]; recomputed after rate changes)
  • Variable beta_a0(VARIABLES[105]; recomputed after rate changes)
  • Variable kb(CONSTANTS[61])
  • Variable kf(CONSTANTS[62])
  • Variable alpha_a1(VARIABLES[106]; recomputed after rate changes)
  • Variable beta_a1(VARIABLES[107]; recomputed after rate changes)
  • Variable alpha_i(VARIABLES[108]; recomputed after rate changes)
  • Variable beta_i(VARIABLES[109]; recomputed after rate changes)
  • Variable i_NaK(VARIABLES[110]; recomputed after rate changes)
  • Variable i_NaK_max(CONSTANTS[63])
  • Variable Km_Nai(CONSTANTS[64])
  • Variable Km_Ko(CONSTANTS[65])
  • Variable f_NaK(VARIABLES[111]; recomputed after rate changes)
  • Variable sigma(VARIABLES[112]; computed once)
• No equation needed for Newton-Raphson evaluation.

void SetupFixedConstants(double* CONSTANTS)
{
CONSTANTS[0] = 0.0005;
CONSTANTS[1] = 0.23324;
CONSTANTS[2] = 20;
CONSTANTS[3] = 1;
CONSTANTS[4] = 0.5;
CONSTANTS[5] = 292.8;
CONSTANTS[6] = 87500;
CONSTANTS[7] = 1380;
CONSTANTS[8] = 0.1;
CONSTANTS[9] = 0.35;
CONSTANTS[10] = 0.000367;
CONSTANTS[11] = 0.006075;
CONSTANTS[12] = 0.07125;
CONSTANTS[13] = 0.00405;
CONSTANTS[14] = 0.965;
CONSTANTS[15] = 0.009;
CONSTANTS[16] = 0.0008;
CONSTANTS[17] = 3;
CONSTANTS[18] = 4;
CONSTANTS[19] = 7;
CONSTANTS[20] = 63;
CONSTANTS[21] = 0.1729;
CONSTANTS[22] = 0.4067;
CONSTANTS[23] = 0;
CONSTANTS[24] = 0.00575;
CONSTANTS[25] = 0.16;
CONSTANTS[26] = 0.00237;
CONSTANTS[27] = 3.2e-05;
CONSTANTS[28] = 0.0327;
CONSTANTS[29] = 0.0196;
CONSTANTS[30] = 4.5;
CONSTANTS[31] = 20;
CONSTANTS[32] = 1.74e-05;
CONSTANTS[33] = 8;
CONSTANTS[34] = 0.45;
CONSTANTS[35] = 0.5;
CONSTANTS[36] = 50;
CONSTANTS[37] = 15000;
CONSTANTS[38] = 0.238;
CONSTANTS[39] = 800;
CONSTANTS[40] = 1;
CONSTANTS[41] = 2.584e-05;
CONSTANTS[42] = 1.2e-07;
CONSTANTS[43] = 2.098e-06;
CONSTANTS[44] = 1.485e-09;
CONSTANTS[45] = 0.0001534;
CONSTANTS[46] = 5400;
CONSTANTS[47] = 140000;
CONSTANTS[48] = 1800;
CONSTANTS[49] = 8.314;
CONSTANTS[50] = 13;
CONSTANTS[51] = 0.0026;
CONSTANTS[52] = 10;
CONSTANTS[53] = -40;
CONSTANTS[54] = 10;
CONSTANTS[55] = 298;
CONSTANTS[56] = 96.5;
CONSTANTS[57] = 70;
CONSTANTS[58] = 140;
CONSTANTS[59] = 0.05;
CONSTANTS[60] = 0.078;
CONSTANTS[61] = 0.036778;
CONSTANTS[62] = 0.023761;
CONSTANTS[63] = 0.88;
CONSTANTS[64] = 21000;
CONSTANTS[65] = 1500;
}

void SetupComputedConstants(double* CONSTANTS, double* VARIABLES)
{
VARIABLES[112] = ((1.00000/7.00000)*(exp((CONSTANTS[47]/67300.0))-1.00000));
VARIABLES[0] = 0.000167740;
VARIABLES[1] = 9.30308e-19;
VARIABLES[2] = 0.000124216;
VARIABLES[3] = 5.78679e-09;
VARIABLES[4] = 1.19816e-13;
VARIABLES[5] = 4.97923e-19;
VARIABLES[6] = 3.45847e-14;
VARIABLES[7] = 1.85106e-14;
VARIABLES[8] = 0.00265563;
VARIABLES[9] = 0.999977;
VARIABLES[10] = 0.000417069;
VARIABLES[11] = 0.998543;
VARIABLES[12] = 0.000262753;
VARIABLES[13] = 0.00000;
VARIABLES[14] = 0.115001;
VARIABLES[15] = 0.115001;
VARIABLES[16] = 1299.50;
VARIABLES[17] = 1299.50;
VARIABLES[18] = -82.4202;
VARIABLES[19] = 14237.1;
VARIABLES[20] = 7.13483e-07;
VARIABLES[21] = 0.000279132;
VARIABLES[22] = 0.0207520;
VARIABLES[23] = 6.73345e-07;
VARIABLES[24] = 1.55787e-09;
VARIABLES[25] = 0.000153176;
VARIABLES[26] = 0.0113879;
VARIABLES[27] = 0.342780;
VARIABLES[28] = 143720.;
VARIABLES[29] = 11.2684;
VARIABLES[30] = 125.290;
VARIABLES[31] = 1.49102e-05;
VARIABLES[32] = 9.51726e-11;
VARIABLES[33] = 0.000417069;
VARIABLES[34] = 0.998543;
VARIABLES[35] = 0.000417069;
VARIABLES[36] = 1.00000;
VARIABLES[37] = 0.000175298;
VARIABLES[38] = 0.000992513;
VARIABLES[39] = 0.000641229;
VARIABLES[40] = 3.19129e-05;
}

void ComputeRates(double* BOUND, double* RATES, double* CONSTANTS, double* VARIABLES)
{
RATES[18] = ((-(VARIABLES[47]+VARIABLES[43]+VARIABLES[44]+VARIABLES[45]+VARIABLES[76]+VARIABLES[93]+VARIABLES[110]+VARIABLES[51]+VARIABLES[57]+VARIABLES[62]+VARIABLES[63]+VARIABLES[66]+VARIABLES[100]+VARIABLES[102]+VARIABLES[94]+VARIABLES[96]))/CONSTANTS[40]);
RATES[14] = (VARIABLES[69]*((VARIABLES[72]+VARIABLES[68])-(VARIABLES[74]+VARIABLES[67]+((((VARIABLES[45]+VARIABLES[43])-(2.00000*VARIABLES[44]))*CONSTANTS[45]*CONSTANTS[40])/(2.00000*CONSTANTS[41]*CONSTANTS[56])))));
RATES[15] = (VARIABLES[70]*(((VARIABLES[73]*CONSTANTS[42])/CONSTANTS[44])-(((VARIABLES[68]*CONSTANTS[41])/CONSTANTS[44])+((VARIABLES[47]*CONSTANTS[45]*CONSTANTS[40])/(2.00000*CONSTANTS[44]*CONSTANTS[56])))));
RATES[16] = (VARIABLES[71]*(VARIABLES[75]-VARIABLES[73]));
RATES[17] = ((((VARIABLES[74]-VARIABLES[72])*CONSTANTS[41])/CONSTANTS[43])-((VARIABLES[75]*CONSTANTS[42])/CONSTANTS[43]));
RATES[13] = (((-0.0400000)*VARIABLES[13])-(((0.100000*VARIABLES[47])/CONSTANTS[19])*exp(((-pow((VARIABLES[18]-5.00000),2.00000))/648.000))));
RATES[29] = ((CONSTANTS[28]*VARIABLES[14]*(CONSTANTS[57]-VARIABLES[29]))-(CONSTANTS[29]*VARIABLES[29]));
RATES[30] = ((CONSTANTS[26]*VARIABLES[14]*(CONSTANTS[58]-VARIABLES[30]))-(CONSTANTS[27]*VARIABLES[30]));
RATES[31] = (((CONSTANTS[11]*pow(VARIABLES[15],CONSTANTS[18])*VARIABLES[97])+(CONSTANTS[14]*VARIABLES[32])+(CONSTANTS[16]*VARIABLES[0]))-((CONSTANTS[12]*VARIABLES[31])+(CONSTANTS[13]*pow(VARIABLES[15],CONSTANTS[17])*VARIABLES[31])+(CONSTANTS[15]*VARIABLES[31])));
RATES[32] = ((CONSTANTS[13]*pow(VARIABLES[15],CONSTANTS[17])*VARIABLES[31])-(CONSTANTS[14]*VARIABLES[32]));
RATES[0] = ((CONSTANTS[15]*VARIABLES[31])-(CONSTANTS[16]*VARIABLES[0]));
RATES[1] = (((VARIABLES[49]*VARIABLES[4])+(CONSTANTS[0]*VARIABLES[5])+(0.00100000*((VARIABLES[49]*VARIABLES[6])-(VARIABLES[42]*VARIABLES[1]))))-((4.00000*VARIABLES[50]*VARIABLES[1])+(VARIABLES[41]*VARIABLES[1])));
RATES[2] = (((4.00000*VARIABLES[49]*VARIABLES[48])+(2.00000*VARIABLES[50]*VARIABLES[3]))-((VARIABLES[50]*VARIABLES[2])+(3.00000*VARIABLES[49]*VARIABLES[2])));
RATES[3] = (((3.00000*VARIABLES[49]*VARIABLES[2])+(3.00000*VARIABLES[50]*VARIABLES[4]))-((2.00000*VARIABLES[50]*VARIABLES[3])+(2.00000*VARIABLES[49]*VARIABLES[3])));
RATES[4] = (((2.00000*VARIABLES[49]*VARIABLES[3])+(4.00000*VARIABLES[50]*VARIABLES[1])+(0.0100000*((4.00000*CONSTANTS[0]*VARIABLES[50]*VARIABLES[5])-(VARIABLES[49]*VARIABLES[41]*VARIABLES[4])))+(0.00200000*((4.00000*VARIABLES[50]*VARIABLES[6])-(VARIABLES[42]*VARIABLES[4])))+(4.00000*VARIABLES[50]*CONSTANTS[0]*VARIABLES[7]))-((3.00000*VARIABLES[50]*VARIABLES[4])+(VARIABLES[49]*VARIABLES[4])+(VARIABLES[41]*VARIABLES[42]*VARIABLES[4])));
RATES[5] = (((VARIABLES[41]*VARIABLES[1])+(0.00100000*((VARIABLES[49]*VARIABLES[7])-(VARIABLES[42]*VARIABLES[5])))+(0.0100000*((VARIABLES[49]*VARIABLES[41]*VARIABLES[4])-(4.00000*VARIABLES[50]*VARIABLES[42]*VARIABLES[5]))))-(CONSTANTS[0]*VARIABLES[5]));
RATES[6] = (((0.00100000*((VARIABLES[42]*VARIABLES[1])-(VARIABLES[49]*VARIABLES[6])))+(CONSTANTS[0]*VARIABLES[7])+(0.00200000*((VARIABLES[42]*VARIABLES[4])-(4.00000*VARIABLES[50]*VARIABLES[6]))))-(VARIABLES[41]*VARIABLES[6]));
RATES[7] = (((0.00100000*((VARIABLES[42]*VARIABLES[5])-(VARIABLES[49]*VARIABLES[7])))+(VARIABLES[41]*VARIABLES[6])+(VARIABLES[41]*VARIABLES[42]*VARIABLES[4]))-((4.00000*VARIABLES[50]*CONSTANTS[0]*VARIABLES[7])+(CONSTANTS[0]*VARIABLES[7])));
RATES[19] = (((-(VARIABLES[76]+VARIABLES[93]+(3.00000*VARIABLES[110])+(3.00000*VARIABLES[44])))*CONSTANTS[45]*CONSTANTS[40])/(CONSTANTS[41]*CONSTANTS[56]));
RATES[22] = (((VARIABLES[79]*VARIABLES[78])+(VARIABLES[82]*VARIABLES[21])+(VARIABLES[85]*VARIABLES[26]))-((VARIABLES[80]*VARIABLES[22])+(VARIABLES[81]*VARIABLES[22])+(VARIABLES[86]*VARIABLES[22])));
RATES[21] = (((VARIABLES[81]*VARIABLES[22])+(VARIABLES[84]*VARIABLES[20])+(VARIABLES[85]*VARIABLES[25]))-((VARIABLES[82]*VARIABLES[21])+(VARIABLES[83]*VARIABLES[21])+(VARIABLES[86]*VARIABLES[21])));
RATES[20] = (((VARIABLES[83]*VARIABLES[21])+(VARIABLES[88]*VARIABLES[25]))-((VARIABLES[84]*VARIABLES[20])+(VARIABLES[87]*VARIABLES[20])));
RATES[25] = (((VARIABLES[87]*VARIABLES[20])+(VARIABLES[86]*VARIABLES[21])+(VARIABLES[90]*VARIABLES[23])+(VARIABLES[81]*VARIABLES[26]))-((VARIABLES[88]*VARIABLES[25])+(VARIABLES[85]*VARIABLES[25])+(VARIABLES[89]*VARIABLES[25])+(VARIABLES[82]*VARIABLES[25])));
RATES[23] = (((VARIABLES[89]*VARIABLES[25])+(VARIABLES[92]*VARIABLES[24]))-((VARIABLES[90]*VARIABLES[23])+(VARIABLES[91]*VARIABLES[23])));
RATES[24] = ((VARIABLES[91]*VARIABLES[23])-(VARIABLES[92]*VARIABLES[24]));
RATES[26] = (((VARIABLES[79]*VARIABLES[27])+(VARIABLES[82]*VARIABLES[25])+(VARIABLES[86]*VARIABLES[26]))-((VARIABLES[80]*VARIABLES[26])+(VARIABLES[81]*VARIABLES[26])+(VARIABLES[85]*VARIABLES[26])));
RATES[27] = (((VARIABLES[80]*VARIABLES[26])+(VARIABLES[86]*VARIABLES[78]))-((VARIABLES[79]*VARIABLES[27])+(VARIABLES[85]*VARIABLES[27])));
RATES[28] = (((-((VARIABLES[51]+VARIABLES[57]+VARIABLES[62]+VARIABLES[63]+VARIABLES[100]+VARIABLES[66]+VARIABLES[102])-(2.00000*VARIABLES[110])))*CONSTANTS[45]*CONSTANTS[40])/(CONSTANTS[41]*CONSTANTS[56]));
RATES[8] = ((VARIABLES[53]*(1.00000-VARIABLES[8]))-(VARIABLES[54]*VARIABLES[8]));
RATES[9] = ((VARIABLES[55]*(1.00000-VARIABLES[9]))-(VARIABLES[56]*VARIABLES[9]));
RATES[10] = ((VARIABLES[58]-VARIABLES[10])/VARIABLES[60]);
RATES[11] = ((VARIABLES[59]-VARIABLES[11])/VARIABLES[61]);
RATES[12] = ((VARIABLES[64]*(1.00000-VARIABLES[12]))-(VARIABLES[65]*VARIABLES[12]));
RATES[33] = ((VARIABLES[58]-VARIABLES[33])/VARIABLES[98]);
RATES[34] = ((VARIABLES[59]-VARIABLES[34])/VARIABLES[99]);
RATES[35] = ((VARIABLES[58]-VARIABLES[35])/VARIABLES[101]);
RATES[36] = 0.00000;
RATES[39] = (((CONSTANTS[62]*VARIABLES[38])+(VARIABLES[107]*VARIABLES[37]))-((CONSTANTS[61]*VARIABLES[39])+(VARIABLES[106]*VARIABLES[39])));
RATES[38] = (((VARIABLES[104]*VARIABLES[103])+(CONSTANTS[61]*VARIABLES[39]))-((VARIABLES[105]*VARIABLES[38])+(CONSTANTS[62]*VARIABLES[38])));
RATES[37] = (((VARIABLES[106]*VARIABLES[39])+(VARIABLES[109]*VARIABLES[40]))-((VARIABLES[107]*VARIABLES[37])+(VARIABLES[108]*VARIABLES[37])));
RATES[40] = ((VARIABLES[108]*VARIABLES[37])-(VARIABLES[109]*VARIABLES[40]));
}

void ComputeVariables(double* BOUND, double* RATES, double* CONSTANTS, double* VARIABLES)
{
VARIABLES[97] = (1.00000-(VARIABLES[0]+VARIABLES[31]+VARIABLES[32]));
VARIABLES[98] = ((0.493000*exp(((-0.0629000)*VARIABLES[18])))+2.05800);
VARIABLES[99] = (1200.00-(170.000/(1.00000+exp(((VARIABLES[18]+45.2000)/5.70000)))));
VARIABLES[52] = (((CONSTANTS[49]*CONSTANTS[55])/CONSTANTS[56])*log((CONSTANTS[46]/VARIABLES[28])));
VARIABLES[100] = (CONSTANTS[59]*VARIABLES[35]*VARIABLES[36]*(VARIABLES[18]-VARIABLES[52]));
VARIABLES[101] = ((39.3000*exp(((-0.0862000)*VARIABLES[18])))+13.1700);
VARIABLES[102] = (CONSTANTS[60]*VARIABLES[37]*(VARIABLES[18]-(((CONSTANTS[49]*CONSTANTS[55])/CONSTANTS[56])*log((((0.980000*CONSTANTS[46])+(0.0200000*CONSTANTS[47]))/((0.980000*VARIABLES[28])+(0.0200000*VARIABLES[19])))))));
VARIABLES[103] = (1.00000-(VARIABLES[38]+VARIABLES[39]+VARIABLES[37]+VARIABLES[40]));
VARIABLES[104] = (0.0223480*exp((0.0117600*VARIABLES[18])));
VARIABLES[105] = (0.0470020*exp(((-0.0631000)*VARIABLES[18])));
VARIABLES[106] = (0.0137330*exp((0.0381980*VARIABLES[18])));
VARIABLES[107] = (6.89000e-05*exp(((-0.0417800)*VARIABLES[18])));
VARIABLES[108] = (0.0908210*exp((0.0233910*(VARIABLES[18]+5.00000))));
VARIABLES[109] = (0.00649700*exp(((-0.0326800)*(VARIABLES[18]+5.00000))));
VARIABLES[111] = (1.00000/(1.00000+(0.124500*exp((((-0.100000)*VARIABLES[18]*CONSTANTS[56])/(CONSTANTS[49]*CONSTANTS[55]))))+(0.0365000*VARIABLES[112]*exp((((-VARIABLES[18])*CONSTANTS[56])/(CONSTANTS[49]*CONSTANTS[55]))))));
VARIABLES[110] = ((((CONSTANTS[63]*VARIABLES[111]*1.00000)/(1.00000+pow((CONSTANTS[64]/VARIABLES[19]),1.50000)))*CONSTANTS[46])/(CONSTANTS[46]+CONSTANTS[65]));
VARIABLES[42] = (13.0000*(1.00000-exp(((-pow((VARIABLES[18]+14.5000),2.00000))/100.000))));
VARIABLES[43] = ((CONSTANTS[3]*pow(VARIABLES[14],2.00000))/(pow(CONSTANTS[4],2.00000)+pow(VARIABLES[14],2.00000)));
VARIABLES[44] = (((((((CONSTANTS[5]*1.00000)/(pow(CONSTANTS[6],3.00000)+pow(CONSTANTS[47],3.00000)))*1.00000)/(CONSTANTS[7]+CONSTANTS[48]))*1.00000)/(1.00000+(CONSTANTS[8]*exp((((CONSTANTS[9]-1.00000)*VARIABLES[18]*CONSTANTS[56])/(CONSTANTS[49]*CONSTANTS[55]))))))*((exp(((CONSTANTS[9]*VARIABLES[18]*CONSTANTS[56])/(CONSTANTS[49]*CONSTANTS[55])))*pow(VARIABLES[19],3.00000)*CONSTANTS[48])-(exp((((CONSTANTS[9]-1.00000)*VARIABLES[18]*CONSTANTS[56])/(CONSTANTS[49]*CONSTANTS[55])))*pow(CONSTANTS[47],3.00000)*VARIABLES[14])));
VARIABLES[69] = pow((1.00000+((CONSTANTS[36]*CONSTANTS[38])/pow((CONSTANTS[38]+VARIABLES[14]),2.00000))),(-1.00000));
VARIABLES[70] = pow((1.00000+((CONSTANTS[36]*CONSTANTS[38])/pow((CONSTANTS[38]+VARIABLES[15]),2.00000))),(-1.00000));
VARIABLES[71] = pow((1.00000+((CONSTANTS[37]*CONSTANTS[39])/pow((CONSTANTS[39]+VARIABLES[16]),2.00000))),(-1.00000));
VARIABLES[72] = (CONSTANTS[32]*(VARIABLES[17]-VARIABLES[14]));
VARIABLES[73] = (CONSTANTS[30]*(VARIABLES[31]+VARIABLES[32])*(VARIABLES[16]-VARIABLES[15])*VARIABLES[13]);
VARIABLES[74] = ((CONSTANTS[34]*pow(VARIABLES[14],2.00000))/(pow(CONSTANTS[35],2.00000)+pow(VARIABLES[14],2.00000)));
VARIABLES[75] = ((VARIABLES[17]-VARIABLES[16])/CONSTANTS[31]);
VARIABLES[77] = (((CONSTANTS[49]*CONSTANTS[55])/CONSTANTS[56])*log((((0.900000*CONSTANTS[47])+(0.100000*CONSTANTS[46]))/((0.900000*VARIABLES[19])+(0.100000*VARIABLES[28])))));
VARIABLES[76] = (CONSTANTS[50]*VARIABLES[20]*(VARIABLES[18]-VARIABLES[77]));
VARIABLES[78] = (1.00000-(VARIABLES[20]+VARIABLES[21]+VARIABLES[22]+VARIABLES[25]+VARIABLES[23]+VARIABLES[24]+VARIABLES[26]+VARIABLES[27]));
VARIABLES[79] = (3.80200/((0.102700*exp(((-(VARIABLES[18]+2.50000))/17.0000)))+(0.200000*exp(((-(VARIABLES[18]+2.50000))/150.000)))));
VARIABLES[80] = (0.191700*exp(((-(VARIABLES[18]+2.50000))/20.3000)));
VARIABLES[81] = (3.80200/((0.102700*exp(((-(VARIABLES[18]+2.50000))/15.0000)))+(0.230000*exp(((-(VARIABLES[18]+2.50000))/150.000)))));
VARIABLES[82] = (0.200000*exp(((-(VARIABLES[18]-2.50000))/20.3000)));
VARIABLES[83] = (3.80200/((0.102700*exp(((-(VARIABLES[18]+2.50000))/12.0000)))+(0.250000*exp(((-(VARIABLES[18]+2.50000))/150.000)))));
VARIABLES[84] = (0.220000*exp(((-(VARIABLES[18]-7.50000))/20.3000)));
VARIABLES[85] = (7.00000e-07*exp(((-(VARIABLES[18]+7.00000))/7.70000)));
VARIABLES[86] = (0.00840000+(2.00000e-05*(VARIABLES[18]+7.00000)));
VARIABLES[87] = (1.00000/((0.188495*exp(((-(VARIABLES[18]+7.00000))/16.6000)))+0.393956));
VARIABLES[88] = ((VARIABLES[83]*VARIABLES[87]*VARIABLES[85])/(VARIABLES[84]*VARIABLES[86]));
VARIABLES[89] = (VARIABLES[87]/1000.00);
VARIABLES[90] = VARIABLES[85];
VARIABLES[91] = (VARIABLES[87]/95000.0);
VARIABLES[92] = (VARIABLES[85]/50.0000);
VARIABLES[93] = (CONSTANTS[51]*(VARIABLES[18]-VARIABLES[77]));
VARIABLES[95] = (0.200000/(1.00000+exp(((-(VARIABLES[18]-46.7000))/7.80000))));
VARIABLES[94] = (((CONSTANTS[52]*VARIABLES[95]*VARIABLES[14])/(VARIABLES[14]+CONSTANTS[54]))*(VARIABLES[18]-CONSTANTS[53]));
VARIABLES[96] = ((((BOUND[0]>=20.0000))&&((BOUND[0]<=20.5000)))) ? ((-80.0000)) : (0.00000);
VARIABLES[46] = (((CONSTANTS[49]*CONSTANTS[55])/(2.00000*CONSTANTS[56]))*log((CONSTANTS[48]/VARIABLES[14])));
VARIABLES[45] = (CONSTANTS[10]*(VARIABLES[18]-VARIABLES[46]));
VARIABLES[47] = (CONSTANTS[21]*VARIABLES[1]*(VARIABLES[18]-CONSTANTS[20]));
VARIABLES[48] = (1.00000-(VARIABLES[1]+VARIABLES[2]+VARIABLES[2]+VARIABLES[3]+VARIABLES[4]+VARIABLES[5]+VARIABLES[6]+VARIABLES[7]));
VARIABLES[49] = ((0.400000*exp(((VARIABLES[18]+12.0000)/10.0000))*((1.00000+(0.700000*exp(((-pow((VARIABLES[18]+40.0000),2.00000))/10.0000))))-(0.750000*exp(((-pow((VARIABLES[18]+20.0000),2.00000))/400.000)))))/(1.00000+(0.120000*exp(((VARIABLES[18]+12.0000)/10.0000)))));
VARIABLES[50] = (0.0500000*exp(((-(VARIABLES[18]+12.0000))/13.0000)));
VARIABLES[51] = (CONSTANTS[22]*pow(VARIABLES[8],3.00000)*VARIABLES[9]*(VARIABLES[18]-VARIABLES[52]));
VARIABLES[53] = (0.180640*exp((0.0357700*(VARIABLES[18]+30.0000))));
VARIABLES[54] = (0.395600*exp(((-0.0623700)*(VARIABLES[18]+30.0000))));
VARIABLES[55] = ((0.000152000*exp(((-(VARIABLES[18]+13.5000))/7.00000)))/((0.00670830*exp(((-(VARIABLES[18]+33.5000))/7.00000)))+1.00000));
VARIABLES[56] = ((0.000950000*exp(((VARIABLES[18]+33.5000)/7.00000)))/((0.0513350*exp(((VARIABLES[18]+33.5000)/7.00000)))+1.00000));
VARIABLES[57] = (CONSTANTS[23]*VARIABLES[10]*VARIABLES[11]*(VARIABLES[18]-VARIABLES[52]));
VARIABLES[58] = (1.00000/(1.00000+exp(((-(VARIABLES[18]+22.5000))/7.70000))));
VARIABLES[59] = (1.00000/(1.00000+exp(((VARIABLES[18]+45.2000)/5.70000))));
VARIABLES[60] = ((0.493000*exp(((-0.0629000)*VARIABLES[18])))+2.05800);
VARIABLES[61] = (270.000+(1050.00/(1.00000+exp(((VARIABLES[18]+45.2000)/5.70000)))));
VARIABLES[62] = ((((0.293800*CONSTANTS[46])/(CONSTANTS[46]+210.000))*(VARIABLES[18]-VARIABLES[52]))/(1.00000+exp((0.0896000*(VARIABLES[18]-VARIABLES[52])))));
VARIABLES[63] = (CONSTANTS[24]*pow(VARIABLES[12],2.00000)*(VARIABLES[18]-VARIABLES[52]));
VARIABLES[64] = (4.81333e-06*(VARIABLES[18]+26.5000)*(1.00000-exp(((-0.128000)*(VARIABLES[18]+26.5000)))));
VARIABLES[65] = (9.53333e-05*exp(((-0.0380000)*(VARIABLES[18]+26.5000))));
VARIABLES[66] = (CONSTANTS[25]*VARIABLES[33]*VARIABLES[34]*(VARIABLES[18]-VARIABLES[52]));
VARIABLES[67] = (((CONSTANTS[26]*VARIABLES[14]*(CONSTANTS[58]-VARIABLES[30]))+(CONSTANTS[28]*VARIABLES[14]*(CONSTANTS[57]-VARIABLES[29])))-((CONSTANTS[27]*VARIABLES[30])+(CONSTANTS[29]*VARIABLES[29])));
VARIABLES[68] = ((VARIABLES[15]-VARIABLES[14])/CONSTANTS[33]);
VARIABLES[41] = ((CONSTANTS[1]*VARIABLES[15])/(CONSTANTS[2]+VARIABLES[15]));
#ifndef VARIABLES_FOR_RATES_ONLY
#endif
}