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Emergent Properties of Networks of Biological Signaling Pathways

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<!--
This CellML file was generated on 20/06/2007 at 12:39:18 at a.m. using:

COR (0.9.31.649)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns="http://www.cellml.org/cellml/1.0#" cmeta:id="bhalla_model_1999" name="bi_model_1999_version01">

<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Emergent properties of networks of biological signaling pathways</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This version of the model describes the complete network of signalling pathways in the original publication.  The model has been checked and it runs in PCEnv.
    </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
In 1999 Upinder S. Bhalla and Ravi Iyengar published a paper discussing the emergent properties of signalling pathway networks.  To develop these networks, they modelled individual pathways and compared those results to previously published results before combining the individual pathways to create networks.  They only used mechanisms that had already been experimentally described when making connections between pathways.  The complete network of reaction pathways they modelled is shown in the figure below.
</para>

<para>
This particular version of the CellML model describes the PKC pathway component of the Bhalla-Iyengar model.
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
Emergent properties of networks of biological signaling pathways. Bhalla US, Iyengar R. <ulink url="http://www.sciencemag.org/">
            <emphasis>Science</emphasis>
          </ulink> 1999 Jan 15; 283(5400); 381-7.  (A <ulink url="http://www.sciencemag.org/cgi/content/full/283/5400/381">full text</ulink> version of the article is available to members on the <emphasis>Science</emphasis> website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9888852&amp;dopt=Abstract">PubMed ID: 9888852</ulink>
</para>


<informalfigure float="0" id="fig_pathway_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>model diagram</title>
    </objectinfo>
    <imagedata fileref="../images/bhalla_model_1999/bhalla_iyengar_pkc.png" />
  </imageobject>
</mediaobject>
<caption>A rendering of the complete signalling network.</caption>
</informalfigure>

</sect1>
</article>
</documentation>



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