Component: environment

Component: Calcium

Component: undefinedvariables

Component: DGBM_Model_Modules

$d Ga_GDP d t = Ga_GTP kfD7 − Ga_GDP kfD8 Gbg + CaGqPLC kfG5 d mGluR d t = kfD5 Gabg_GluR − kbD5 Gabg mGluR − kfD3 mGluR − kbD3 Glu R + kfD6 Gabg_GluR d Gabg d t = Ga_GDP Gbg kfD8 − Gabg R kfD4 − Gabg_R kbD4 + kfD5 Gabg_GluR − kbD5 Gabg mGluR − kfD9 Gabg GTP d R d t = kfD3 mGluR − kbD3 Glu R − Gabg R kfD4 − Gabg_R kbD4 d Gbg d t = Ga_GDP Gbg kfD8 + kfD6 Gabg_GluR + kfD9 Gabg GTP − kfB8 GEF Gbg − kbB8 Gbg_GEF d Gabg_R d t = Gabg R kfD4 − Gabg_R kbD4 + kfD2 Gabg_GluR − Gabg_R Glu kbD2 d Glu_synapse d t = − (kfD1 Glu_synapse − kbD1 Glu) d Gabg_GluR d t = − (kfD2 Gabg_GluR − Gabg_R Glu kbD2) − kfD5 Gabg_GluR − kbD5 Gabg mGluR − kfD6 Gabg_GluR d Glu d t = kfD1 Glu_synapse − kbD1 Glu + kfD2 Gabg_GluR − Gabg_R Glu kbD2 + kfD3 mGluR − kbD3 Glu R d Ga_GTP d t = kfD9 Gabg GTP − Ga_GTP kfD7 − PLC Ga_GTP kfG2 − GqPLC kbG2 − CaGqPLC kbG4 + CaPLC Ga_GTP kfG4 d PLC d t = − (PLC Ca kfG1 − CaPLC kbG1) − PLC Ga_GTP kfG2 − GqPLC kbG2 d GqPLC d t = PLC Ga_GTP kfG2 − GqPLC kbG2 − Ca GqPLC kfG3 − CaGqPLC kbG3 d CaPLC d t = PLC Ca kfG1 − CaPLC kbG1 + CaGqPLC kfG5 − CaGqPLC kbG4 + CaPLC Ga_GTP kfG4 d CaGqPLC d t = GqPLC Ca kfG3 − CaGqPLC kbG3 + CaPLC Ga_GTP kfG4 − CaGqPLC kbG4 − CaGqPLC kfG5 d GEF_inact d t = PKA VmaxB1 GEF / (kmB1 + GEF) − kfB2 GEF_inact d GEF d t = − (PKA VmaxB1 GEF / (kmB1 + GEF) + PKC VmaxB6 GEF / (kmB6 (one + GAP / kmB3 + Ng / kmM7 + Raf / kmH1 + NgCaM / kmM8) + GEF) − kfB2 GEF_inact − kfB7 GEF_star) − kfB5 Ca4CAM GEF + kbB5 CaM_GEF − kfB8 GEF Gbg + kbB8 Gbg_GEF d CaM_GEF d t = kbB5 CaM_GEF + kfB5 GEF Ca4CAM d Ca4CAM d t = − (kbB5 CaM_GEF + kfB5 GEF Ca4CAM) + Ca Ca3CaM kfM3 − kbM3 Ca4CAM d Gbg_GEF d t = − (kfB8 GEF Gbg + kbB8 Gbg_GEF) d GEF_star d t = PKC VmaxB6 GEF / (kmB6 (one + GAP / kmB3 + Ng / kmM7 + Raf / kmH1 + NgCaM / kmM8) + GEF) − kfB7 GEF_star d CaM d t = − (kfM1 Ca Ca CaM − kbM1 Ca2CaM) − kfM4 Ng CaM − kbM4 NgCaM + NgCaM PKC VmaxM8 / (NgCaM + kmM8) d NgCaM d t = kfM4 Ng CaM − kbM4 NgCaM − NgCaM PKC VmaxM8 / (NgCaM + kmM8 (one + GAP / kmB3 + GEF / kmB6 + Raf / kmH1 + Ng / kmM7)) d Ca2CaM d t = kfM1 Ca Ca CaM − kbM1 Ca2CaM − Ca Ca2CaM kfM2 − kbM2 Ca3CaM d Ca3CaM d t = Ca Ca2CaM kfM2 − kbM2 Ca3CaM − Ca Ca3CaM kfM3 − kbM3 Ca4CAM d Ng_star d t = NgCaM PKC VmaxM8 / (NgCaM + kmM8 (one + GAP / kmB3 + GEF / kmB6 + Raf / kmH1 + Ng / kmM7)) − kfM6 Ng_star − VmaxM5 Ng_star / (Ng_star + kmM5) + Ng PKC VmaxM7 / (Ng + kmM7 (one + GAP / kmB3 + GEF / kmB6 + Raf / kmH1 + NgCaM / kmM8)) d Ng d t = kfM6 Ng_star + VmaxM5 Ng_star / (Ng_star + kmM5) − Ng PKC VmaxM7 / (Ng + kmM7 (one + GAP / kmB3 + GEF / kmB6 + Raf / kmH1 + NgCaM / kmM8))$

Component: B_Model_Modules

$d GTP_RAS d t = − GAP VmaxB13 GTP_RAS / (kmB13 + GTP_RAS) − kfB12 GTP_RAS + GEF_star VmaxB10 GDP_RAS / (kmB10 + GDP_RAS) + Gbg_GEF VmaxB11 GDP_RAS / (kmB11 + GDP_RAS) + CaM_GEF VmaxB9 GDP_RAS / (kmB9 + GDP_RAS) + SHCstar_SOS_GRB2 VmaxA7 GDP_RAS / (kmA7 + GDP_RAS) − GTP_RAS Raf_star kfH5 + GTPRasRaf_star kbH5 d GDP_RAS d t = − (− GAP VmaxB13 GTP_RAS / (kmB13 + GTP_RAS) − kfB12 GTP_RAS + GEF_star VmaxB10 GDP_RAS / (kmB10 + GDP_RAS) + Gbg_GEF VmaxB11 GDP_RAS / (kmB11 + GDP_RAS) + CaM_GEF VmaxB9 GDP_RAS / (kmB9 + GDP_RAS)) − SHCstar_SOS_GRB2 VmaxA7 GDP_RAS / (kmA7 + GDP_RAS) d GAP d t = − PKC VmaxB3 GAP / (kmB3 (one + Raf / kmH1 + GEF / kmB6 + Ng / kmM7 + NgCaM / kmM8) + GAP) + kfB4 GAPstar d GAPstar d t = PKC VmaxB3 GAP / (kmB3 (one + Raf / kmH1 + GEF / kmB6 + Ng / kmM7 + NgCaM / kmM8) + GAP) − kfB4 GAPstar d GTPRasRaf_star d t = GTP_RAS Raf_star kfH5 − GTPRasRaf_star kbH5 d Raf d t = − PKC Raf VmaxH1 / (kmH1 (one + GAP / kmB3 + GEF / kmB6 + Ng / kmM7 + NgCaM / kmM8) + Raf) + Raf_star PP2A VmaxH3 / (kmH3 (one + Raf_star_star / kmH4 + MAPKK_star_star / kmH9 + MAPKK_star / kmH8) + Raf_star) d Raf_star d t = PKC Raf VmaxH1 / (kmH1 (one + GAP / kmB3 + GEF / kmB6 + Ng / kmM7 + NgCaM / kmM8) + Raf) − Raf_star PP2A VmaxH3 / (kmH3 (one + Raf_star_star / kmH4 + MAPKK_star_star / kmH9 + MAPKK_star / kmH8) + Raf_star) − Raf_star MAPK_star VmaxH2 / (kmH2 (one + SOS / kmA9) + Raf_star) + Raf_star_star PP2A VmaxH4 / (kmH4 (one + Raf_star / kmH3 + MAPKK_star_star / kmH9 + MAPKK_star / kmH8) + Raf_star_star) d Raf_star_star d t = Raf_star MAPK_star VmaxH2 / (kmH2 (one + SOS / kmA9) + Raf_star) − Raf_star_star PP2A VmaxH4 / (kmH4 (one + Raf_star / kmH3 + MAPKK_star_star / kmH9 + MAPKK_star / kmH8) + Raf_star_star)$

Component: H_Model_Module_MAPKK

$d MAPKK d t = − MAPKK VmaxH6 GTPRasRaf_star / (kmH6 (one + MAPKK_star / kmH7) + MAPKK) + MAPKK_star VmaxH8 PP2A / (kmH8 (one + Raf_star / kmH3 + Raf_star_star / kmH4 + MAPKK_star_star / kmH9) + MAPKK_star) d MAPKK_star d t = MAPKK VmaxH6 GTPRasRaf_star / (kmH6 (one + MAPKK_star / kmH7) + MAPKK) − MAPKK_star VmaxH8 PP2A / (kmH8 (one + Raf_star / kmH3 + Raf_star_star / kmH4 + MAPKK_star_star / kmH9) + MAPKK_star) − MAPKK_star VmaxH7 GTPRasRaf_star / (kmH7 (one + MAPKK / kmH6) + MAPKK_star) + MAPKK_star_star VmaxH9 PP2A / (kmH9 (one + Raf_star / kmH3 + Raf_star_star / kmH4 + MAPKK_star / kmH8) + MAPKK_star_star) d MAPKK_star_star d t = MAPKK_star VmaxH7 GTPRasRaf_star / (kmH7 (one + MAPKK / kmH6) + MAPKK_star) − MAPKK_star_star VmaxH9 PP2A / (kmH9 (one + Raf_star / kmH3 + Raf_star_star / kmH4 + MAPKK_star / kmH8) + MAPKK_star_star)$

Component: H_Model_Module_MAPK

$d MAPK d t = − MAPK VmaxH10 MAPKK_star_star / (kmH10 (one + MAPK_tyr / kmH11) + MAPK) + MAPK_tyr VmaxH12 MKP1 / (kmH12 (one + MAPK_star / kmH13) + MAPK_tyr) d MAPK_tyr d t = MAPK VmaxH10 MAPKK_star_star / (kmH10 MAPK_tyr / kmH11 + MAPK) − MAPK_tyr VmaxH12 MKP1 / (kmH12 (one + MAPK_star / kmH13) + MAPK_tyr) − MAPK_tyr VmaxH11 MAPKK_star_star / (kmH11 (one + MAPK_tyr / kmH12) + MAPK_tyr) + MAPK_star VmaxH13 MKP1 / (kmH13 (one + MAPK_tyr / kmH12) + MAPK_star) d MAPK_star d t = MAPK_tyr VmaxH11 MAPKK_star_star / (kmH11 (one + MAPK / kmH10) + MAPK_tyr) − MAPK_star VmaxH13 MKP1 / (kmH13 (one + MAPK_tyr / kmH12) + MAPK_star)$

Component: A_Model_Module_SHC

$d SHCstar d t = EGF_EGFR VmaxA3 SHC / (kmA3 (one + CaPLCg / kmF4) + SHC) − kfA6 SHCstar SOS_GRB2 + kbA6 SHCstar_SOS_GRB2 − kfA4 SHCstar d SHC d t = kfA4 SHCstar − kbA4 SHC − EGF_EGFR VmaxA3 SHC / (kmA3 (one + CaPLCg / kmF4) + SHC) d SHCstar_SOS_GRB2 d t = kfA6 SHCstar SOS_GRB2 − kbA6 SHCstar_SOS_GRB2 d SOS_GRB2 d t = kfA6 SHCstar SOS_GRB2 + kbA6 SHCstar_SOS_GRB2 − kbA5 SOS_GRB2 + kfA5 SOS GRB2 d SOS d t = kfA8 SOSstar − kbA8 SOS − MAPK_star VmaxA9 SOS / (kmA9 (one + Raf_star / kmH2) + SOS) + kbA5 SOS_GRB2 − kfA5 SOS GRB2 d SOSstar d t = kfA8 SOSstar + kbA8 SOS + MAPK_star VmaxA9 SOS / (kmA9 (one + Raf_star / kmH2) + SOS) − kfA10 SOSstar GRB2 + kbA10 SOSstar_GRB2 d SOSstar_GRB2 d t = kfA10 SOSstar GRB2 − kbA10 SOSstar_GRB2 d GRB2 d t = kbA5 SOS_GRB2 − kfA5 SOS GRB2 − kfA10 SOSstar GRB2 + kbA10 SOSstar_GRB2$

Component: A_Model_Module_EGFR

$d EGF d t = kfA1 EGF EGFR + kbA1 EGF_EGFR d EGFR d t = kfA1 EGF EGFR + kbA1 EGF_EGFR d EGF_EGFR d t = kfA1 EGF EGFR − kbA1 EGF_EGFR − kfA2 EGF_EGFR + kbA2 EGF_EGFR_INTERNAL d EGF_EGFR_INTERNAL d t = kfA2 EGF_EGFR − kbA2 EGF_EGFR_INTERNAL$

Component: F_Model_Module_PLC

$d PLCg d t = Ca PLCg kfF1 + CaPLCg kbF1 d CaPLCg d t = − (Ca PLCg kfF1 + CaPLCg kbF1) + kfF3 CaPLCg_star − VmaxF4 EGF_EGFR CaPLCg / (kmF4 (one + SHC / kmA3) + CaPLCg) d CaPLCg_star d t = − (kfF3 CaPLCg_star − VmaxF4 EGF_EGFR CaPLCg / (kmF4 + CaPLCg)) + Ca PLCg_star kfF5 − kbF5 CaPLCg_star d PLCg_star d t = Ca PLCg_star kfF5 + kbF5 CaPLCg_star$

Component: KEL_DAGIP3_Model_Modules

$d PKC_i d t = PKC_i kfK1 + PKC kbK1 − PKC_i AA kfK2 + PKC kbK2 − PKC_i DAG kfK9 + DAGPKC kbK9 − PKC_i Ca kfK7 + CaPKC kbK7 d DAGPKC d t = PKC_i DAG kfK9 − DAGPKC kbK9 − DAGPKC AA kfK10 + AADAGPKC kbK10 d AADAGPKC d t = DAGPKC AA kfK10 − AADAGPKC kbK10 − AADAGPKC kfK6 + PKC kbK6 d CaPKC d t = PKC_i Ca kfK7 − CaPKC kbK7 − CaPKC kfK3 + PKC kbK3 − CaPKC AA kfK4 + PKC kbK4 − DAG CaPKC kfK8 + DAGCaPKC kbK8 d DAGCaPKC d t = DAG CaPKC kfK8 − DAGCaPKC kbK8 − DAGCaPKC kfK5 + PKC kbK5 d PKC d t = PKC_i kfK1 − PKC kbK1 + PKC_i AA kfK2 − PKC kbK2 + CaPKC kfK3 − PKC kbK3 + CaPKC AA kfK4 − PKC kbK4 + DAGCaPKC kfK5 − PKC kbK5 + AADAGPKC kfK6 − PKC kbK6 d AA d t = PKC_i AA kfK2 + PKC kbK2 − CaPKC AA kfK4 + PKC kbK4 − DAGPKC AA kfK10 + AADAGPKC kbK10 − AA kfE13 + CaPLA2_star VmaxE12 APC / (kmE12 + APC) + CaPLA2 VmaxE4 APC / (kmE4 + APC) + DAGCaPLA2 VmaxE8 APC / (kmE8 + APC) + PIP2CaPLA2 VmaxE6 APC / (kmE6 + APC) + PIP2PLA2 VmaxE2 APC / (kmE2 + APC) d PLA2_cyt d t = PLA2_star kfE10 − PIP2_star PLA2_cyt kfE1 + PIP2PLA2 kbE1 − Ca PLA2_cyt kfE3 + CaPLA2 kbE3 − MAPK VmaxE9 PLA2_cyt / (kmE9 + PLA2_cyt) d PIP2PLA2 d t = PIP2_star PLA2_cyt kfE1 − PIP2PLA2 kbE1 d PIP2_star d t = PIP2_star PLA2_cyt kfE1 + PIP2PLA2 kbE1 − PIP2_star CaPLA2 kfE5 + PIP2CaPLA2 kbE5 d PLA2_star d t = PLA2_star kfE10 + MAPK VmaxE9 PLA2_cyt / (kmE9 + PLA2_cyt) − Ca PLA2_star kfE11 + CaPLA2_star kbE11 d CaPLA2_star d t = Ca PLA2_star kfE11 − CaPLA2_star kbE11 d CaPLA2 d t = Ca PLA2_cyt kfE3 − CaPLA2 kbE3 − DAG CaPLA2 kfE7 + DAGCaPLA2 kbE7 − PIP2_star CaPLA2 kfE5 + PIP2CaPLA2 kbE5 d PIP2CaPLA2 d t = PIP2_star CaPLA2 kfE5 − PIP2CaPLA2 kbE5 d DAGCaPLA2 d t = DAG CaPLA2 kfE7 − DAGCaPLA2 kbE7 d APC d t = AA kfE13 − CaPLA2_star VmaxE12 APC / (kmE12 + APC) + CaPLA2 VmaxE4 APC / (kmE4 + APC) + DAGCaPLA2 VmaxE8 APC / (kmE8 + APC) + PIP2CaPLA2 VmaxE6 APC / (kmE6 + APC) + PIP2PLA2 VmaxE2 APC / (kmE2 + APC) d PIP2 d t = − CaPLCg VmaxF2 PIP2 / (kmF2 + PIP2) − CaPLCg_star VmaxF6 PIP2 / (kmF6 + PIP2) − CaPLC VmaxG7 PIP2 / (kmG7 + PIP2) − CaGqPLC VmaxG6 PIP2 / (kmG6 + PIP2) d DAG d t = CaPLCg VmaxF2 PIP2 / (kmF2 + PIP2) + CaPLCg_star VmaxF6 PIP2 / (kmF6 + PIP2) + CaPLC VmaxG7 PIP2 / (kmG7 + PIP2) − kfG8 DAG + CaGqPLC VmaxG6 PIP2 / (kmG6 + PIP2) − PKC_i DAG kfK9 + DAGPKC kbK9 − DAG CaPKC kfK8 + DAGCaPKC kbK8 − DAG CaPLA2 kfE7 + DAGCaPLA2 kbE7 d IP3 d t = CaPLCg VmaxF2 PIP2 / (kmF2 + PIP2) + CaPLCg_star VmaxF6 PIP2 / (kmF6 + PIP2) + CaGqPLC VmaxG6 PIP2 / (kmG6 + PIP2) − kfG9 IP3 + CaPLC VmaxG7 PIP2 / (kmG7 + PIP2) d PC d t = kfG8 DAG d Inositol d t = kfG9 IP3$