Component: environment

Component: membrane

$d V d time = − (i_K + i_K_Ca + i_K_ATP + i_Ca_f + i_Ca_s + i_CRAC) / Cm$

Component: delayed_rectifier_K_channel_current

$i_K = g_K n (V − V_K)$

Component: delayed_rectifier_K_channel_current_n_gate

$d n d time = (n_infinity − n) / tau_n n_infinity = 1.0 / (1.0 + e (Vn − V) / Sn) tau_n = 4.86 / (1.0 + e (V + 15.0) / 6.0)$

Component: K_ATP_channel_current

$i_K_ATP = g_K_ATP (V − V_K)$

Component: fast_Ca_channel_current

$i_Ca_f = g_Ca_f m_f_infinity (V − V_Ca)$

Component: fast_Ca_channel_current_m_f_gate

$m_f_infinity = 1.0 / (1.0 + e (Vm_f − V) / Sm_f)$

Component: slow_Ca_channel_current

$i_Ca_s = g_Ca_s j m_s_infinity (V − V_Ca)$

Component: slow_Ca_channel_current_m_s_gate

$m_s_infinity = 1.0 / (1.0 + e (Vm_s − V) / Sm_s)$

Component: slow_Ca_channel_current_j_gate

$d j d time = (j_infinity − j) / tau_j j_infinity = 1.0 / (1.0 + e (Vj − V) / Sj) tau_j = 50000.0 / (e (V + 53.0) / 4.0 + e − (V + 53.0) / 4.0 + 1500.0)$

Component: Ca_activated_K_current

$i_K_Ca = g_K_Ca Ca_i 5.0 / (Ca_i 5.0 + 0.55 5.0) (V − V_K)$

Component: CRAC_current

$i_CRAC = g_CRAC r_infinity Ca_er (V − V_CRAC)$

Component: CRAC_current_r_gate

$r_infinity = 1.0 / (1.0 + e Ca_er − 3.0)$

Component: calcium_handling_equations

$d Ca_i d time = 1.0 / lamda ((P_leak / P_ip3 + O_infinity) (Ca_er − Ca_i) − J_er / P_ip3) + J_mem / Vi_eff d Ca_er d time = − (1.0 / lamda sigma) ((P_leak / P_ip3 + O_infinity) (Ca_er − Ca_i) − J_er / P_ip3) Vi_eff = Vi / fi Ver_eff = Ver / fer lamda = Vi_eff / P_ip3 sigma = Ver_eff / Vi_eff O_infinity = a_infinity b_infinity h_infinity a_infinity = Ca_i / (Ca_i + 0.1) b_infinity = IP3 / (IP3 + 0.2) h_infinity = 0.4 / (Ca_i + 0.4) J_er_p = P_ip3 Ver_p Ca_i 2.0 / (Ca_i 2.0 + 0.09 2.0)$

Component: calcium_flux_through_the_plasma_membrane

$J_mem = − alpha (i_Ca_s + i_Ca_f) − K_Ca Ca_i$

Component: calcium_flux_through_the_ER_membrane

$J_er = (P_leak + P_ip3 O_infinity) (Ca_er − Ca_i) − J_er_p$