Component: environment

Component: membrane

$d V d time = − (i_Ca + i_K + i_K_Ca + i_K_ATP) / Cm$

Component: delayed_rectifier_potassium_current

$i_K = g_K n (V − V_K)$

Component: delayed_rectifier_potassium_current_n_gate

$d n d time = (n_infinity − n) / tau_n n_infinity = 1.0 / (1.0 + e − (16.0 + V) / 5.0)$

Component: calcium_current

$i_Ca = g_Ca m_infinity (V − V_Ca)$

Component: calcium_current_m_gate

$m_infinity = 1.0 / (1.0 + e − (20.0 + V) / 12.0)$

Component: calcium_dependent_potassium_current

$i_K_Ca = g_K_Ca (V − V_K) g_K_Ca = g_K_Ca_Ca 5.0 / (kD 5.0 + Ca 5.0)$

Component: nucleotide_sensitive_potassium_current

$i_K_ATP = g_K_ATP (V − V_K) g_K_ATP = g_K_ATP_O_infinity_ADP_ATP MgADP = 0.165 ADP ADP3 = 0.135 ADP ATP4 = 0.05 ATP O_infinity_ADP_ATP = (0.08 (1.0 + 2.0 MgADP / 17.0) + 0.89 (MgADP / 17.0) 2.0) / (1.0 + MgADP / 17.0) 2.0 (1.0 + ADP3 / 26.0 + ATP4 / 1.0)$

Component: cytosolic_free_calcium_concentration

$d Ca d time = fcyt (Jmem + Jer)$

Component: calcium_flux_through_the_membrane

$Jmem = − (alpha i_Ca + kPMCA Ca)$

Component: net_calcium_efflux_out_of_the_ER

$Jer = Jleak − J_SERCA$

Component: calcium_leak_out_of_the_ER

$Jleak = pleak (Ca_er − Ca)$

Component: calcium_influx_into_the_ER

$J_SERCA = kSERCA Ca$

Component: ER_calcium_concentration

$d Ca_er d time = − fer Vcyt_Ver Jer$

Component: glycolysis

$d G6P d time = lamda (R_GK − R_PFK) d FBP d time = lamda (R_PFK − 0.5 R_GPDH) F6P = 0.3 G6P R_GPDH = 0.2 (FBP / 1.0) 0.5 R_PFK = Vmax (W11100 + lamda1 (sum_state fraction_state − W11100)) / sum_state fraction_state fraction_state = 1.0 / f13 (alpha gamma) f23 (beta gamma) f41 (delta alpha) f42 (delta beta) f43 (delta gamma) f53 (epsilon gamma) AMP alpha / K1 alpha FBP beta / K2 beta F6P (2.0 gamma) / K3 gamma ATP delta / K4 delta ATP epsilon / K5 epsilon W00000$

Component: adenine_nucleotides

$d ADP d time = (ATP − ADP e (r + gamma) (1.0 − Ca / r1)) / tau_a AMP = ADP 2.0 / ATP ATP = A_tot − ADP + AMP gamma = v_gamma R_GPDH / (k_gamma + R_GPDH)$