Component: environment

Component: membrane

$d V d time = (− (i_Na + i_Ca + i_to + i_K + i_K1 + i_b_Na + i_b_Ca + i_NaCa + i_NaK) + (rho_x S) -1.0 V_x2 + (rho_y S) -1.0 V_y2) / Cm x V = V_x2 y V = V_y2$

Component: sodium_current

$i_Na = g_Na m 3.0 v 2.0 (V − E_Na) E_Na = R T / F ln (Na_e / Na_i)$

Component: sodium_current_m_gate

$d m d time = alpha_m (1.0 − m) − beta_m m alpha_m = 0.32 (V + 47.13) / (1.0 − e -0.1 (V + 47.13)) beta_m = 0.08 e − V / 11.0$

Component: sodium_current_v_gate

$d v d time = (v_infinity − v) / tau_v v_infinity = 0.5 (1.0 − tanh (7.74 + V × 0.12)) tau_v = 0.25 + 2.24 (1.0 − tanh (7.74 + V × 0.12)) / (1.0 − tanh (0.07 (V + 92.4)))$

Component: calcium_current

$i_Ca = g_Ca d_infinity f f_Ca (V − E_Ca) E_Ca = R T / 2.0 F ln (Ca_e / Ca_i)$

Component: calcium_current_d_gate

$d_infinity = alpha_d / (alpha_d + beta_d) alpha_d = 14.98 e − 0.5 ((V − 22.36) / 16.68) 2.0 / 16.68 2.0 π beta_d = 0.1471 − 5.3 e − 0.5 ((V − 6.27) / 14.93) 2.0 / 14.93 2.0 π$

Component: calcium_current_f_gate

$d f d time = alpha_f (1.0 − f) − beta_f f alpha_f = 6.87E-3 / (1.0 + e − (6.1546 − V) / 6.12) beta_f = (0.069 e -11.0 (V + 9.825) + 0.011) / (1.0 + e -0.278 (V + 9.825)) + 5.75E-4$

Component: calcium_current_f_Ca_gate

$f_Ca = 1.0 / (1.0 + Ca_i / 0.0006)$

Component: transient_outward_current

$i_to = g_to r_infinity to (V − E_to) E_to = R T / F ln ((0.043 Na_e + K_e) / (0.043 Na_i + K_i))$

Component: transient_outward_current_r_gate

$r_infinity = alpha_r / (alpha_r + beta_r) alpha_r = 0.5266 e − 0.0166 (V − 42.2912) / (1.0 + e − 0.0943 (V − 42.2912)) beta_r = (5.186E-5 V + 0.5149 e − 0.1344 (V − 5.0027)) / (1.0 + e − 0.1348 (V − 5.186E-5))$

Component: transient_outward_current_to_gate

$d to d time = alpha_to (1.0 − to) − beta_to to alpha_to = (5.612E-5 V + 0.0721 e -0.173 (V + 34.2531)) / (1.0 + e -0.1732 (V + 34.2531)) beta_to = (1.215E-4 V + 0.0767 e -1.66E-9 (V + 34.0235)) / (1.0 + e − 0.1604 (V + 34.0235)) tau_to = 1.0 / (p alpha_to V + p beta_to V) to_infinity = alpha_to (V − V_shift) / (alpha_to (V − V_shift) + beta_to (V − V_shift))$

Component: delayed_rectifier_potassium_current

$i_K = g_K X 2.0 (V − E_K) E_K = R T / F ln (K_e / K_i)$

Component: delayed_rectifier_potassium_current_X_gate

$d X d time = (X_infinity − X) / tau_X X_infinity = 0.988 / (1.0 + e -0.861 − V × 0.0620) tau_X = 240.0 e − (25.5 + V) 2.0 / 156.0 + 182.0 (1.0 + tanh (0.154 + 0.0116 V)) + tau_X_a tau_X_a = 40.0 (1.0 − tanh (160.0 + 2.0 V))$

Component: inward_rectifier_potassium_current

$i_K1 = g_K1 K1_infinity (V − E_K)$

Component: inward_rectifier_potassium_current_K1_gate

$K1_infinity = alpha_K1 / (alpha_K1 + beta_K1) alpha_K1 = 0.1 / (1.0 + e 0.06 (V − E_K + 200.0)) beta_K1 = (3.0 e 2.0E-4 (V + 100.0 + − E_K) + e 0.1 (V − 10.0 + E_K)) / (1.0 + e − 0.5 (V − E_K))$

Component: calcium_background_current

$i_b_Ca = g_b_Ca (V − E_Ca)$

Component: sodium_background_current

$i_b_Na = g_b_Na (V − E_Na)$

Component: sodium_potassium_pump

$i_NaK = g_NaK f_NaK f_NaK_a f_NaK = 1.0 / (1.0 + 0.1245 e -0.0037 V + 0.0365 sigma e -0.037 V) f_NaK_a = 1.0 / (1.0 + (10.0 / Na_i) 1.5) K_e / (K_e + 1.5) sigma = 0.1428 (e Na_e / 67.3 − 1.0)$

Component: sodium_calcium_pump

$i_NaCa = g_NaCa f_NaCa f_NaCa = (87.5 3.0 + Na_e 3.0) -1.0 (1.38 + Ca_e) -1.0 (1.0 + 0.1 e -0.024 V) -1.0 (Na_i 3.0 Ca_e e 0.013 V − Na_e 3.0 Ca_i e -0.024 V)$