Component: environment

Component: G_o

Component: G

$d G d time = V_IN − V_HK$

Component: G6P

$d G6P d time = V_HK − V_PFK + V_G6PDH$

Component: FDP

$d FDP d time = V_PFK − V_ALD$

Component: G3P

$d G3P d time = 2.0 V_ALD − V_GAPDH$

Component: DPG

$d DPG d time = V_GAPDH − V_PGK$

Component: PEP

$d PEP d time = V_PGK − V_PK$

Component: Py

$d Py d time = V_PK − V_TCA + V_ADH$

Component: ATP

$d ATP d time = V_PGK + V_PK + PO V_TCA − V_HK + V_PFK + V_ATPase$

Component: ADP

Component: AMP

Component: Cn

$Cn = ATP + ADP + AMP$

Component: GTP

Component: GDP

Component: H

Component: NADP

Component: NADH

Component: NAD

Component: CD

Component: CT

$d CT d time = − (kpol CT CP 2.0 + kf CD + kb CT GDP)$

Component: CP

$d CP d time = kpol CT CP 2.0 − kdp CP$

Component: CMTP

$CMTP = CD + CT + CP$

Component: PKp

$d PKp d time = 0.1 kp2 PKt CP − kp3 PKp + k4 PKp GTP$

Component: PKt

Component: C_PK

$C_PK = PKt + PKp$

Component: V_IN

$V_IN = V_IN_max G_o / (KG_in + G_o) (1.0 + G6P / Ke_in) − G / (KG_in + G) (1.0 + G6P / Ke_in)$

Component: V_HK

$V_HK = V_HK_max 1.0 / (1.0 + KG_s KATP_m / G ATP + KG_m / G + KATP_m / ATP)$

Component: V_PFK

$V_PFK = V_PFK_max gr G6P / KG6P_r ATP / KATP_r (1.0 + G6P / KG6P_r + ATP / KATP_r + gr G6P / KG6P_r ATP / KATP_r) (n1 − 1.0) / ((1.0 + G6P / KG6P_r + ATP / KATP_r + gr G6P / KG6P_r ATP / KATP_r) n1 + Lo ((1.0 + cAMP AMP / KAMP_r) / (1.0 + AMP / KAMP_r)) n1 (1.0 + cG6P G6P / KG6P_r + cATP ATP / KATP_r + gr cG6P G6P / KG6P_r cATP ATP / KATP_r) n1)$

Component: V_G6PDH

$V_G6PDH = V_G6PDH_max / (KG6P KNADP / G6P NADP + KG6P / G6P + KNADP / NADP + 1.0) + V_G6PDH_max_II / (KG6P KNADP_KTUB / G6P NADP TUB + KG6P KNADP_/ G6P NADP + KNADP_KTUB / NADP TUB + KG6P KTUB / G6P TUB + KTUB / TUB + KG6P / G6P + KNADP_/ NADP + 1.0) TUB = CT + CD$

Component: V_ALD

$V_ALD = (V_ALD_max FDP / KFDP_m − V_ALD_max_r G3P / KG3P_m) / (1.0 + FDP / KFDP_m + G3P / KG3P_m)$

Component: V_GAPDH

$V_GAPDH = V_GAPDH_max / (1.0 + KG3P / G3P + KNAD / NAD (1.0 + AMP / K1 + ADP / K2 + ATP / K3) + KG3P KNAD / G3P NAD (1.0 + NADH / KNADH_i) + 1.0 + AMP / K1 + ADP / K2 + ATP / K3)$

Component: V_PGK

$V_PGK = V_PGK_max DPG / (KDPG_m + DPG)$

Component: V_PK

$V_PK = V_PK_max / (1.0 + KpH / H) (gr_PK PEP / KPEP_r ADP / KADP_r R n + Lo_PK ((1.0 + cFDP FDP / KFDP_r) / (1.0 + FDP / KFDP_r)) n FDP / KFDP_r gt_PK cPEP PEP / KPEP_r cADP ADP / KADP_r T (1.0 − n)) / (R n + Lo_PK ((1.0 + cFDP FDP / KFDP_r) / (1.0 + FDP / KFDP_r)) n T n) R = 1.0 + PEP / KPEP_r + ADP / KADP_r + gr_PK PEP / KPEP_r ADP / KADP_r T = 1.0 + cPEP PEP / KPEP_r + cADP ADP / KADP_r + gt_PK cPEP PEP / KPEP_r cADP ADP / KADP_r V_PK_max = V_PKt_max − V_PKp_max PKp / C_PK n = 4.0 + PKp / C_PK$

Component: V_TCA

$V_TCA = V_TCA_max Py 2.0 / (KPy_m 2.0 + Py 2.0)$

Component: V_ADH

$V_ADH = V_ADH_max Py / (KPy__m + Py)$

Component: V_ATPase

$V_ATPase = KATP ATP$