Component: environment

Component: cytoplasmic_calcium

d Ca_i d time =− J_i J_i = J_pm + J_ER

Component: intraluminal_calcium

d Ca_ER d time = J_ER v_i k_i / v_ER k_ER Ca_ER_init = Ca_i + J_SERCA Ca_i / P_ER Ca_i / v_i

Component: total_cytoplasmic_Ca_flux

J_ICa = I_Ca / 2.0 F v_i k_i

Component: Ca_extrusion_across_the_plasma_membrane

J_pm = J_extru + J_ICa J_extru = k_i -1.0 ( k_leak_pm ( Ca_i − Ca_o )+ Vmax_extru /( 1.0 +( EC50_extru / Ca_i ) n_extru ))

Component: Ca_uptake_by_SR_Ca_ATPase

J_SERCA = Vmax_SERCA / k_i ( 1.0 +( EC50_SERCA / Ca_i ) n_SERCA )

Component: ER_Ca_release

J_release = P_ER ( Ca_i − Ca_ER )/ v_i k_i J_ER = J_SERCA + J_release P_ER = v_i ( P_basal + Pmax_RyR /( 1.0 +( EC50_RyR / Ca_i ) n_RyR ))