The Calmodulin Kinase II (CaMKII) Pathway Model from Bhalla and Iyengar

In 1999 Upinder S. Bhalla and Ravi Iyengar published a paper discussing the emergent properties of signalling pathway networks. To develop these networks, they modelled individual pathways and compared those results to previously published results before combining the individual pathways to create networks. They only used mechanisms that had already been experimentally described when making connections between pathways. One of the reaction pathways they modelled was the calmodulin kinase II (CaMKII) pathway (see Figure 1 below).

The complete original paper reference is cited below:

Emergent properties of networks of biological signaling pathways. Bhalla US, Iyengar R. Science 1999 Jan 15; 283(5400); 381-7. (The full text of the article is available to members on the Science website.) PubMed ID: 9888852

The raw CellML description of the CaMKII pathway model can be downloaded in various formats as described in the section “Download This Model”. For an example of a more complete documentation of another real reaction pathway, see The Bhalla Iyengar EGF Pathway Model, 1999.

Figure 1. A rendering of the CaMKII pathway. Species are represented by rounded rectangles, and reactions by arrows. The action of a catalyst on a reaction is represented by dashed lines.