Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-06-17 Added more metadata. Lloyd Catherine May 2002-07-22 The University of Auckland, Bioengineering Institute A Generic Model Of Triacylglycerol Synthesis Below is a CellML description of a general model of triacylglycerol synthesis. It is not based on a specific published mathematical model, but instead it is based on a textbook defined pathway. The general sequential structure and all the reactant, product and enzyme components are included. Michaelis-Menten enzyme kinetics are assumed. The purpose of this description is to illustrate how CellML can be used to model a general metabolic pathway. Catherine Lloyd Homo sapiens keyword metabolism Bronk J Ramsey Human Metabolism 1999 Addison Wesley Longman Limited location England $\frac{d \mathrm{Glycerol\_3\_phosphate}}{d \mathrm{time}}=\mathrm{delta\_Glycerol\_3\_phosphate\_rxn0}$ $\frac{d \mathrm{Lysophosphatidate}}{d \mathrm{time}}=\mathrm{delta\_Lysophosphatidate\_rxn0}+\mathrm{delta\_Lysophosphatidate\_rxn1}$ $\frac{d \mathrm{Phosphatidate}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidate\_rxn1}+\mathrm{delta\_Phosphatidate\_rxn2}$ $\frac{d \mathrm{Diacylglycerol}}{d \mathrm{time}}=\mathrm{delta\_Diacylglycerol\_rxn2}+\mathrm{delta\_Diacylglycerol\_rxn3}$ $\frac{d \mathrm{fatty\_acid}}{d \mathrm{time}}=\mathrm{delta\_fatty\_acid\_rxn0}+\mathrm{delta\_fatty\_acid\_rxn1}+\mathrm{delta\_fatty\_acid\_rxn3}$ $\frac{d \mathrm{CoA\_SH}}{d \mathrm{time}}=\mathrm{delta\_CoA\_SH\_rxn0}+\mathrm{delta\_CoA\_SH\_rxn1}+\mathrm{delta\_CoA\_SH\_rxn3}$ $\frac{d \mathrm{H2O}}{d \mathrm{time}}=\mathrm{delta\_H2O\_rxn2}$ $\frac{d \mathrm{Pi}}{d \mathrm{time}}=\mathrm{delta\_Pi\_rxn2}$ $\frac{d \mathrm{Triacylglycerol}}{d \mathrm{time}}=\mathrm{delta\_Triacylglycerol\_rxn3}$ $\mathrm{rate}=\frac{\mathrm{vmax0}\mathrm{Glycerol\_3\_phosphate}\mathrm{fatty\_acid}}{\mathrm{km0}+\mathrm{Glycerol\_3\_phosphate}+\mathrm{fatty\_acid}}$ $\mathrm{rate}=\frac{\mathrm{Lysophosphatidate}\mathrm{fatty\_acid}\mathrm{vmax1}}{\mathrm{km1}+\mathrm{Lysophosphatidate}+\mathrm{fatty\_acid}}$ $\mathrm{rate}=\frac{\mathrm{Phosphatidate}\mathrm{H2O}\mathrm{vmax2}}{\mathrm{km2}+\mathrm{Phosphatidate}+\mathrm{H2O}}$ $\mathrm{rate}=\frac{\mathrm{Diacylglycerol}\mathrm{fatty\_acid}\mathrm{vmax3}}{\mathrm{km3}+\mathrm{Diacylglycerol}+\mathrm{fatty\_acid}}$