Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-06-17 Added more metadata. Lloyd Catherine May 2002-07-22 The University of Auckland, Bioengineering Institute A Generic Model Of The Electron Transport Chain Below is a CellML description of a general model of the electron transport chain. It is not based on a specific published mathematical model, but instead it is based on a textbook defined pathway. The general sequential structure and all the reactant, product and enzyme components are included. Michaelis-Menten enzyme kinetics are assumed. The purpose of this description is to illustrate how CellML can be used to model a general metabolic pathway. Catherine Lloyd Homo sapiens Mitochondrion keyword metabolism Bronk J Ramsey Human Metabolism 1999 Addison Wesley Longman Limited location England $\frac{d \mathrm{NADH}}{d \mathrm{time}}=\mathrm{delta\_NADH\_rxn0}$ $\frac{d \mathrm{NAD}}{d \mathrm{time}}=\mathrm{delta\_NAD\_rxn0}$ $\frac{d \mathrm{CoQ\_oxidised}}{d \mathrm{time}}=\mathrm{delta\_CoQ\_oxidised\_rxn1}+\mathrm{delta\_CoQ\_oxidised\_rxn0}+\mathrm{delta\_CoQ\_oxidised\_rxn3}$ $\frac{d \mathrm{CoQ\_reduced}}{d \mathrm{time}}=\mathrm{delta\_CoQ\_reduced\_rxn0}+\mathrm{delta\_CoQ\_reduced\_rxn3}+\mathrm{delta\_CoQ\_reduced\_rxn1}$ $\frac{d \mathrm{Cytochrome\_c\_oxidised}}{d \mathrm{time}}=\mathrm{delta\_Cytochrome\_c\_oxidised\_rxn2}+\mathrm{delta\_Cytochrome\_c\_oxidised\_rxn1}$ $\frac{d \mathrm{Cytochrome\_c\_reduced}}{d \mathrm{time}}=\mathrm{delta\_Cytochrome\_c\_reduced\_rxn1}+\mathrm{delta\_Cytochrome\_c\_reduced\_rxn2}$ $\frac{d \mathrm{H2O}}{d \mathrm{time}}=\mathrm{delta\_H2O\_rxn2}$ $\frac{d \mathrm{O2}}{d \mathrm{time}}=\mathrm{delta\_O2\_rxn2}$ $\frac{d H}{d \mathrm{time}}=\mathrm{delta\_H\_rxn2}$ $\frac{d \mathrm{FAD}}{d \mathrm{time}}=\mathrm{delta\_FAD\_rxn3}$ $\frac{d \mathrm{FADH2}}{d \mathrm{time}}=\mathrm{delta\_FADH2\_rxn4}+\mathrm{delta\_FADH2\_rxn3}$ $\frac{d \mathrm{ATP}}{d \mathrm{time}}=\mathrm{delta\_ATP\_rxn0}+\mathrm{delta\_ATP\_rxn1}+\mathrm{delta\_ATP\_rxn2}$ $\frac{d \mathrm{ADP}}{d \mathrm{time}}=\mathrm{delta\_ADP\_rxn0}+\mathrm{delta\_ADP\_rxn1}+\mathrm{delta\_ADP\_rxn2}$ $\frac{d \mathrm{Pi}}{d \mathrm{time}}=\mathrm{delta\_Pi\_rxn0}+\mathrm{delta\_Pi\_rxn1}+\mathrm{delta\_Pi\_rxn2}$ $\frac{d \mathrm{Succinate}}{d \mathrm{time}}=\mathrm{delta\_Succinate\_rxn4}$ $\frac{d \mathrm{Fumarate}}{d \mathrm{time}}=\mathrm{delta\_Fumarate\_rxn4}$ $\mathrm{rate}=\frac{\mathrm{vmax0}\mathrm{NADH}\mathrm{CoQ\_oxidised}\mathrm{Pi}\mathrm{ADP}}{\mathrm{km0}+\mathrm{NADH}+\mathrm{CoQ\_oxidised}+\mathrm{Pi}+\mathrm{ADP}}$ $\mathrm{rate}=\frac{\mathrm{CoQ\_reduced}\mathrm{Cytochrome\_c\_oxidised}\mathrm{ADP}\mathrm{Pi}\mathrm{vmax1}}{\mathrm{km1}+\mathrm{CoQ\_reduced}+\mathrm{Cytochrome\_c\_oxidised}+\mathrm{ADP}+\mathrm{Pi}}$ $\mathrm{rate}=\frac{\mathrm{CoQ\_oxidised}\mathrm{FADH2}\mathrm{vmax3}}{\mathrm{km3}+\mathrm{CoQ\_oxidised}+\mathrm{FADH2}}$ $\mathrm{rate}=\frac{\mathrm{Succinate}\mathrm{vmax4}}{\mathrm{km4}+\mathrm{Succinate}}$