Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-06-14 Added more metadata. Lloyd Catherine May 2002-07-22 The University of Auckland, Bioengineering Institute A Generic Model Of Phospholipid Synthesis Below is a CellML description of a general model of phospholipid synthesis. It is not based on a specific published mathematical model, but instead it is based on a textbook defined pathway. The general sequential structure and all the reactant, product and enzyme components are included. Michaelis-Menten enzyme kinetics are assumed. The purpose of this description is to illustrate how CellML can be used to model a general metabolic pathway. Catherine Lloyd Homo sapiens keyword metabolism Bronk J Ramsey Human Metabolism 1999 Addison Wesley Longman Limited location England $\frac{d \mathrm{Choline}}{d \mathrm{time}}=\mathrm{delta\_Choline\_rxn0}$ $\frac{d \mathrm{ATP}}{d \mathrm{time}}=\mathrm{delta\_ATP\_rxn0}+\mathrm{delta\_ATP\_rxn4}$ $\frac{d \mathrm{ADP}}{d \mathrm{time}}=\mathrm{delta\_ADP\_rxn0}+\mathrm{delta\_ADP\_rxn4}$ $\frac{d \mathrm{Phosphorylcholine}}{d \mathrm{time}}=\mathrm{delta\_Phosphorylcholine\_rxn0}+\mathrm{delta\_Phosphorylcholine\_rxn1}$ $\frac{d \mathrm{CDP\_choline}}{d \mathrm{time}}=\mathrm{delta\_CDP\_choline\_rxn1}+\mathrm{delta\_CDP\_choline\_rxn2}$ $\frac{d \mathrm{CTP}}{d \mathrm{time}}=\mathrm{delta\_CTP\_rxn1}+\mathrm{delta\_CTP\_rxn5}+\mathrm{delta\_CTP\_rxn8}$ $\frac{d \mathrm{PPi}}{d \mathrm{time}}=\mathrm{delta\_PPi\_rxn1}+\mathrm{delta\_PPi\_rxn5}+\mathrm{delta\_PPi\_rxn8}$ $\frac{d \mathrm{CDP}}{d \mathrm{time}}=\mathrm{delta\_CDP\_rxn2}$ $\frac{d \mathrm{Diacylglycerol}}{d \mathrm{time}}=\mathrm{delta\_Diacylglycerol\_rxn7}+\mathrm{delta\_Diacylglycerol\_rxn2}+\mathrm{delta\_Diacylglycerol\_rxn6}$ $\frac{d \mathrm{Phosphatidyl\_choline}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidyl\_choline\_rxn2}$ $\frac{d \mathrm{Phosphatidyl\_ethanolamine}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidyl\_ethanolamine\_rxn6}+\mathrm{delta\_Phosphatidyl\_ethanolamine\_rxn3}$ $\frac{d \mathrm{Serine}}{d \mathrm{time}}=\mathrm{delta\_Serine\_rxn3}$ $\frac{d \mathrm{Phosphatidyl\_serine}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidyl\_serine\_rxn3}$ $\frac{d \mathrm{Ethanolamine}}{d \mathrm{time}}=\mathrm{delta\_Ethanolamine\_rxn3}+\mathrm{delta\_Ethanolamine\_rxn4}$ $\frac{d \mathrm{Phosphorylethanolamine}}{d \mathrm{time}}=\mathrm{delta\_Phosphorylethanolamine\_rxn4}+\mathrm{delta\_Phosphorylethanolamine\_rxn5}$ $\frac{d \mathrm{CDP\_ethanolamine}}{d \mathrm{time}}=\mathrm{delta\_CDP\_ethanolamine\_rxn5}+\mathrm{delta\_CDP\_ethanolamine\_rxn6}$ $\frac{d \mathrm{CMP}}{d \mathrm{time}}=\mathrm{delta\_CMP\_rxn6}+\mathrm{delta\_CMP\_rxn9}$ $\frac{d \mathrm{Phosphatidate}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidate\_rxn7}+\mathrm{delta\_Phosphatidate\_rxn8}$ $\frac{d \mathrm{H2O}}{d \mathrm{time}}=\mathrm{delta\_H2O\_rxn7}$ $\frac{d \mathrm{Pi}}{d \mathrm{time}}=\mathrm{delta\_Pi\_rxn7}$ $\frac{d \mathrm{CDP\_diacylglycerol}}{d \mathrm{time}}=\mathrm{delta\_CDP\_diacylglycerol\_rxn8}+\mathrm{delta\_CDP\_diacylglycerol\_rxn9}$ $\frac{d \mathrm{Inositol}}{d \mathrm{time}}=\mathrm{delta\_Inositol\_rxn9}$ $\frac{d \mathrm{Phosphatidyl\_inositol}}{d \mathrm{time}}=\mathrm{delta\_Phosphatidyl\_inositol\_rxn9}$ $\mathrm{rate}=\frac{\mathrm{Choline}\mathrm{ATP}\mathrm{vmax0}}{\mathrm{km0}+\mathrm{Choline}+\mathrm{ATP}}$ $\mathrm{rate}=\frac{\mathrm{Phosphorylcholine}\mathrm{CTP}\mathrm{vmax1}}{\mathrm{km1}+\mathrm{Phosphorylcholine}+\mathrm{CTP}}$ $\mathrm{rate}=\frac{\mathrm{CDP\_choline}\mathrm{Diacylglycerol}\mathrm{vmax2}}{\mathrm{km2}+\mathrm{CDP\_choline}+\mathrm{Diacylglycerol}}$ $\mathrm{rate}=\mathrm{k3}\mathrm{Phosphatidyl\_ethanolamine}\mathrm{Serine}$ $\mathrm{rate}=\frac{\mathrm{ATP}\mathrm{Ethanolamine}\mathrm{vmax4}}{\mathrm{km4}+\mathrm{ATP}+\mathrm{Ethanolamine}}$ $\mathrm{rate}=\frac{\mathrm{CTP}\mathrm{Phosphorylethanolamine}\mathrm{vmax5}}{\mathrm{km5}+\mathrm{CTP}+\mathrm{Phosphorylethanolamine}}$ $\mathrm{rate}=\frac{\mathrm{Diacylglycerol}\mathrm{CDP\_ethanolamine}\mathrm{vmax6}}{\mathrm{km6}+\mathrm{Diacylglycerol}+\mathrm{CDP\_ethanolamine}}$ $\mathrm{rate}=\mathrm{k7}\mathrm{H2O}\mathrm{Phosphatidate}$ $\mathrm{rate}=\frac{\mathrm{CTP}\mathrm{Phosphatidate}\mathrm{vmax8}}{\mathrm{km8}+\mathrm{CTP}+\mathrm{Phosphatidate}}$ $\mathrm{rate}=\frac{\mathrm{CDP\_diacylglycerol}\mathrm{Inositol}\mathrm{vmax9}}{\mathrm{km9}+\mathrm{CDP\_diacylglycerol}+\mathrm{Inositol}}$