Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-06-14 The University of Auckland, Bioengineering Institute A Generic Model Of Glycolipid Synthesis Below is a CellML description of a general model of glycolipid synthesis. It is not based on a specific published mathematical model, but instead it is based on a textbook defined pathway. The general sequential structure and all the reactant, product and enzyme components are included. Michaelis-Menten enzyme kinetics are assumed. The purpose of this description is to illustrate how CellML can be used to model a general metabolic pathway. Catherine Lloyd Homo sapiens keyword metabolism Bronk J Ramsey Human Metabolism 1999 Addison Wesley Longman Limited location England $\frac{d \mathrm{Palmitoyl\_CoA}}{d \mathrm{time}}=\mathrm{delta\_Palmitoyl\_CoA\_rxn0}$ $\frac{d \mathrm{Serine}}{d \mathrm{time}}=\mathrm{delta\_Serine\_rxn0}$ $\frac{d \mathrm{Dehydrosphinganine}}{d \mathrm{time}}=\mathrm{delta\_Dehydrosphinganine\_rxn0}+\mathrm{delta\_Dehydrosphinganine\_rxn1}$ $\frac{d \mathrm{CoA\_SH}}{d \mathrm{time}}=\mathrm{delta\_CoA\_SH\_rxn0}+\mathrm{delta\_CoA\_SH\_rxn2}$ $\frac{d \mathrm{CO2}}{d \mathrm{time}}=\mathrm{delta\_CO2\_rxn0}$ $\frac{d \mathrm{NADPH}}{d \mathrm{time}}=\mathrm{delta\_NADPH\_rxn1}$ $\frac{d \mathrm{NADP}}{d \mathrm{time}}=\mathrm{delta\_NADP\_rxn1}$ $\frac{d H}{d \mathrm{time}}=\mathrm{delta\_H\_rxn1}$ $\frac{d \mathrm{Dehydrosphingasine}}{d \mathrm{time}}=\mathrm{delta\_Dehydrosphingasine\_rxn1}+\mathrm{delta\_Dehydrosphingasine\_rxn2}$ $\frac{d \mathrm{Dihydroceramide}}{d \mathrm{time}}=\mathrm{delta\_Dihydroceramide\_rxn2}+\mathrm{delta\_Dihydroceramide\_rxn3}$ $\frac{d \mathrm{FAD}}{d \mathrm{time}}=\mathrm{delta\_FAD\_rxn3}$ $\frac{d \mathrm{FADH2}}{d \mathrm{time}}=\mathrm{delta\_FADH2\_rxn3}$ $\frac{d \mathrm{Fatty\_acyl\_CoA}}{d \mathrm{time}}=\mathrm{delta\_Fatty\_acyl\_CoA\_rxn2}$ $\frac{d \mathrm{Ceramide}}{d \mathrm{time}}=\mathrm{delta\_Ceramide\_rxn3}+\mathrm{delta\_Ceramide\_rxn4}+\mathrm{delta\_Ceramide\_rxn5}$ $\frac{d \mathrm{Galactocerebroside}}{d \mathrm{time}}=\mathrm{delta\_Galactocerebroside\_rxn4}$ $\frac{d \mathrm{Glucocerebroside}}{d \mathrm{time}}=\mathrm{delta\_Glucocerebroside\_rxn5}$ $\frac{d \mathrm{UDP\_galactose}}{d \mathrm{time}}=\mathrm{delta\_UDP\_galactose\_rxn4}$ $\frac{d \mathrm{UDP}}{d \mathrm{time}}=\mathrm{delta\_UDP\_rxn4}+\mathrm{delta\_UDP\_rxn5}$ $\frac{d \mathrm{UDP\_glucose}}{d \mathrm{time}}=\mathrm{delta\_UDP\_glucose\_rxn5}$ $\mathrm{rate}=\frac{\mathrm{Serine}\mathrm{Palmitoyl\_CoA}\mathrm{vmax0}}{\mathrm{km0}+\mathrm{Serine}+\mathrm{Palmitoyl\_CoA}}$ $\mathrm{rate}=\frac{\mathrm{Dehydrosphinganine}\mathrm{NADPH}H\mathrm{vmax1}}{\mathrm{km1}+\mathrm{Dehydrosphinganine}+\mathrm{NADPH}+H}$ $\mathrm{rate}=\frac{\mathrm{Fatty\_acyl\_CoA}\mathrm{Dehydrosphingasine}\mathrm{vmax2}}{\mathrm{km2}+\mathrm{Fatty\_acyl\_CoA}+\mathrm{Dehydrosphingasine}}$ $\mathrm{rate}=\frac{\mathrm{FAD}\mathrm{Dihydroceramide}\mathrm{vmax3}}{\mathrm{km3}+\mathrm{FAD}+\mathrm{Dihydroceramide}}$ $\mathrm{rate}=\frac{\mathrm{Ceramide}\mathrm{UDP\_galactose}\mathrm{vmax4}}{\mathrm{km4}+\mathrm{Ceramide}+\mathrm{UDP\_galactose}}$ $\mathrm{rate}=\frac{\mathrm{Ceramide}\mathrm{UDP\_glucose}\mathrm{vmax5}}{\mathrm{km5}+\mathrm{Ceramide}+\mathrm{UDP\_glucose}}$