Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-10-29 Changed the model name so the model loads in the database easier. Cuellar Autumn A 2003-04-05 The University of Auckland, Bioengineering Institute Kamp and Hell's 2000 kinetic analysis of the regulation of cardiac L-type Ca2+ channels by protein kinase A. This is the CellML descripition of Kamp and Hell's 2000 kinetic analysis of the regulation of cardiac L-type Ca2+ channels by protein kinase A. Catherine Lloyd keyword signal transduction 11110765 Kamp Timothy J Hell Johannes W Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C 2000-12-08 Circulation Research 87 1095 1102 $\frac{d \mathrm{Beta1\_AR}}{d \mathrm{time}}=\mathrm{delta\_Beta1\_AR\_rxn1}$ $\frac{d \mathrm{active\_Gs}}{d \mathrm{time}}=\mathrm{delta\_active\_Gs\_rxn7}$ $\frac{d \mathrm{active\_AC}}{d \mathrm{time}}=\mathrm{delta\_active\_AC\_rxn4}$ $\frac{d \mathrm{M2}}{d \mathrm{time}}=\mathrm{delta\_M2\_rxn0}$ $\frac{d \mathrm{active\_Gi}}{d \mathrm{time}}=\mathrm{delta\_active\_Gi\_rxn10}$ $\frac{d \mathrm{ATP}}{d \mathrm{time}}=\mathrm{delta\_ATP\_rxn3}$ $\frac{d \mathrm{cAMP}}{d \mathrm{time}}=\mathrm{delta\_cAMP\_rxn3}+\mathrm{delta\_cAMP\_rxn12}$ $\frac{d \mathrm{L\_type\_Ca\_channel}}{d \mathrm{time}}=\mathrm{delta\_L\_type\_Ca\_channel\_rxn13}$ $\frac{d \mathrm{active\_PKA}}{d \mathrm{time}}=\mathrm{delta\_active\_PKA\_rxn14}$ $\frac{d \mathrm{Beta2\_AR}}{d \mathrm{time}}=\mathrm{delta\_Beta2\_AR\_rxn2}$ $\frac{d P}{d \mathrm{time}}=\mathrm{delta\_P\_rxn13}$ $\frac{d \mathrm{Adrenaline}}{d \mathrm{time}}=\mathrm{delta\_Adrenaline\_rxn1}+\mathrm{delta\_Adrenaline\_rxn2}$ $\frac{d \mathrm{Acetylcholine}}{d \mathrm{time}}=\mathrm{delta\_Acetylcholine\_rxn0}$ $\frac{d \mathrm{Acetylcholine\_M2\_complex}}{d \mathrm{time}}=\mathrm{delta\_Acetylcholine\_M2\_complex\_rxn0}$ $\frac{d \mathrm{Adrenaline\_beta1\_AR\_complex}}{d \mathrm{time}}=\mathrm{delta\_Adrenaline\_beta1\_AR\_complex\_rxn1}$ $\frac{d \mathrm{Adrenaline\_beta2\_AR\_complex}}{d \mathrm{time}}=\mathrm{delta\_Adrenaline\_beta2\_AR\_complex\_rxn2}$ $\frac{d \mathrm{inactive\_AC}}{d \mathrm{time}}=\mathrm{delta\_inactive\_AC\_rxn4}$ $\frac{d \mathrm{inactive\_Gs}}{d \mathrm{time}}=\mathrm{delta\_inactive\_Gs\_rxn7}$ $\frac{d \mathrm{inactive\_Gi}}{d \mathrm{time}}=\mathrm{delta\_inactive\_Gi\_rxn10}$ $\frac{d \mathrm{AMP}}{d \mathrm{time}}=\mathrm{delta\_AMP\_rxn12}$ $\frac{d \mathrm{Phosphorylated\_active\_L\_type\_Ca\_channel}}{d \mathrm{time}}=\mathrm{delta\_Phosphorylated\_active\_L\_type\_Ca\_channel\_rxn13}$ $\frac{d \mathrm{inactive\_PKA}}{d \mathrm{time}}=\mathrm{delta\_inactive\_PKA\_rxn14}$ $\frac{d \mathrm{Extracellular\_Ca}}{d \mathrm{time}}=\mathrm{delta\_Extracellular\_Ca\_rxn18}$ $\frac{d \mathrm{Intracellular\_Ca}}{d \mathrm{time}}=\mathrm{delta\_Intracellular\_Ca\_rxn18}$ $\mathrm{rate}=\mathrm{k0}\mathrm{M2}\mathrm{Acetylcholine}$ $\mathrm{rate}=\mathrm{k1}\mathrm{Beta1\_AR}\mathrm{Adrenaline}$ $\mathrm{rate}=\mathrm{k2}\mathrm{Adrenaline}\mathrm{Beta2\_AR}$ $\mathrm{rate}=\frac{\mathrm{ATP}\mathrm{vmax3}}{\mathrm{km3}+\mathrm{ATP}}$ $\mathrm{rate}=\frac{\mathrm{cAMP}\mathrm{vmax12}}{\mathrm{km12}+\mathrm{cAMP}}$