<?xml version="1.0"?>
<!--
FILE : bi_egf_pathway_1999_raw.xml
CREATED : 11 November 2000
LAST MODIFIED : 9th April 2003
AUTHOR : Melanie Nelson
Physiome Sciences, Inc.
DESCRIPTION : This file contains a CellML description of the EGF pathway
model from Bhalla and Iyengar.
CHANGES:
25/05/2002 - AAC - Updated metadata to conform to the 16/1/02 CellML Metadata
1.0 Specification.
08/03/2002 - AAC - Fixed connection/variable errors.
22/07/2002 - CML - Added more metadata.
09/04/2003 - AAC - Added publication date information.
24/12/2004 - CML - Corrected model errors - there are still more but I don't really understand Melanie's method of coding!.
-->
<model name="bi_egf_pathway_1999" cmeta:id="bi_egf_pathway_1999" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:mathml="http://www.w3.org/1998/Math/MathML">
<!--
This RDF block contains metadata that applies to the entire model.
The CellML development team recommends that RDF metadata about an element
be included as a child of the element. However, the RDF spec does not
require this. Metadata can be placed anywhere in the model document, or
even in another document, as long as the <rdf:Description> elements contain
about attributes that refer to the correct resource. Because this is an
example, reasonably extensive metadata has been included. The CellML
development team recommends that model authors include as much metadata
as possible because this will make it easier for others to find and
use the model. However, no metadata is required.
-->
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<!--
The following RDF block contains metadata that applies to this document
as a whole, as indicated by the empty about attribute on the
<rdf:Description> element.
-->
<rdf:Description rdf:about="">
<!-- The Human Readable Name metadata. -->
<dc:title>
Epidermal growth factor stimulation of mitogen-associated protein
kinase and activation of Ras
</dc:title>
<!--
The Model Builder metadata. The CellML spec recommends that the
creator element be used to indicate the person who coded the model
into CellML, rather than the person who originally developed the
model. The information about the person who originally developed
the model is available via the reference metadata.
-->
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nelson</vCard:Family>
<vCard:Given>Melanie</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>mnelson@physiome.com</rdf:value>
<rdf:type rdf:resource="http://imc/org/vCard/3.0#internet" />
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Physiome Sciences, Inc.</vCard:Orgname>
</vCard:ORG>
<vCard:ADR rdf:parseType="Resource">
<vCard:Extadd>Physiome Sciences, Inc.</vCard:Extadd>
<vCard:Street>150 College Road West</vCard:Street>
<vCard:Locality>Princeton</vCard:Locality>
<vCard:Region>NJ</vCard:Region>
<vCard:Country>USA</vCard:Country>
<vCard:Pcode>08540-6604</vCard:Pcode>
</vCard:ADR>
<vCard:TEL rdf:parseType="Resource">
<rdf:value>1-609-987-1199</rdf:value>
<rdf:type rdf:resource="http://imc/org/vCard/3.0#work" />
</vCard:TEL>
<vCard:TEL rdf:parseType="Resource">
<rdf:value>1-609-987-9393</rdf:value>
<rdf:type rdf:resource="http://imc/org/vCard/3.0#fax" />
</vCard:TEL>
</dc:creator>
<!--
The Creation Date metadata. This is the date on which the model
was coded into CellML, not the date on which it was originally
created (if it was originally created in a different language)
or the date on which it was published.
-->
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2000-10-11</dcterms:W3CDTF>
</dcterms:created>
<!--
The Modification History metadata. This is the list of modifications
made to the CellML description of the model with the date the
modifications were made and the name of the person(s) who made the
changes.
-->
<cmeta:modification rdf:parseType="Resource">
<rdf:value>
Updated CellML to conform with the 10/8/2001 CellML Version 1.0
Specification.
</rdf:value>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2001-08-02</dcterms:W3CDTF>
</dcterms:modified>
<cmeta:modifier rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cuellar</vCard:Family>
<vCard:Given>Autumn</vCard:Given>
<vCard:Other>A.</vCard:Other>
</vCard:N>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
<vCard:Orgname>The University of Auckland</vCard:Orgname>
</vCard:ORG>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>a.cuellar@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc/org/vCard/3.0#internet" />
</vCard:EMAIL>
</cmeta:modifier>
</cmeta:modification>
</rdf:Description>
<!--
The following metadata refers to the model itself, as indicated by the
reference to the ID "bi_egf_pathway_1999", which is declared on
the <model> element.
-->
<rdf:Description rdf:about="#bi_egf_pathway_1999">
<!-- A human readable name for the model. -->
<dc:title>Bhalla and Iyengar's EGF Pathway, 1999</dc:title>
<!-- A comment regarding the model. -->
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This is the CellML description of Bhalla and Iyengar's mathematical
model of the EGF pathway (1999).
</rdf:value>
<!-- The creator of the comment. -->
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<!-- Keyword(s) -->
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>signal transduction</rdf:value>
</dc:subject>
</bqs:reference>
<!--
The CellML Metadata Specification recommends that bibliographic metadata
is used to provide information about the original model reference. The
"identifier" attribute on the "BibliographicReference" class provides an
elegant way to identify a cited reference using a database identifier such as Pubmed. All associated data such as author, journal title,
date, etc can be looked up on the database.
-->
<bqs:reference rdf:parseType="Resource">
<bqs:Pubmed_id>99105994</bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator>
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Bhalla</vCard:Family>
<vCard:Given>Upinder</vCard:Given>
<vCard:Other>S</vCard:Other>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Iyengar</vCard:Family>
<vCard:Given>Ravi</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>
Emergent Properties of Networks of Biological Signaling Pathways
</dc:title>
<dcterms:issued rdf:parseType="Resource">
<dcterms:W3CDTF>1999-01-15</dcterms:W3CDTF>
</dcterms:issued>
<bqs:Journal rdf:parseType="Resource">
<dc:title>Science</dc:title>
</bqs:Journal>
<bqs:volume>283</bqs:volume>
<bqs:first_page>381</bqs:first_page>
<bqs:last_page>387</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<!--
We start the model definition with a definition of some named
sets of units for use throughout the model.
-->
<units name="concentration_units">
<unit prefix="milli" units="mole" />
<unit units="litre" exponent="-1" />
</units>
<units name="rate_units">
<unit units="concentration_units" />
<unit units="second" exponent="-1" />
</units>
<units name="first_order_rate_constant_units">
<unit units="second" exponent="-1" />
</units>
<units name="second_order_rate_constant_units">
<unit units="concentration_units" exponent="-1" />
<unit units="second" exponent="-1" />
</units>
<units name="third_order_rate_constant_units">
<unit units="concentration_units" exponent="-2" />
<unit units="second" exponent="-1" />
</units>
<!--
The environment component is used to declare variables
that are used by all or most of the other components. Variables
must be declared inside of a <component> element.
-->
<component name="environment">
<variable name="time" public_interface="out" units="second" />
</component>
<!--
The first set of elements define a subsystem that handles the
formation of the active EGF-EGFR complex.
-->
<component name="EGF" cmeta:id="EGF">
<!-- This block of metadata applies only to the EGF component. -->
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGF">
<!-- Human Readable Name metadata. -->
<dc:title>epidermal growth factor</dc:title>
<!--
The Biological Entity metadata. This metadata has a
different meaning than the alias metadata provided above,
even though the two pieces of metadata happen to have the
same value in this example. The <dc:title> element provides a human
readable name for the component. The <cmeta:bio_entity> element
provides information about the biological entity which the component
is meant to represent.
-->
<cmeta:bio_entity>epidermal growth factor</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<!--
The initial_value attribute on a <variable> element declares a value of
the variable when all of the model's independent variables have a value of
0.0. It is anticipated that initial values and other model boundary
conditions would typically be set in an external simulation configuration
file.
-->
<variable name="EGF" public_interface="out" initial_value="0.0" units="concentration_units" />
<variable name="delta_EGF" public_interface="in" units="rate_units" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<apply><diff />
<bvar><ci> time </ci></bvar>
<ci> EGF </ci>
</apply>
<ci> delta_EGF </ci>
</apply>
</math>
</component>
<component name="EGFR" cmeta:id="EGFR">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGFR">
<dc:title>epidermal growth factor receptor</dc:title>
<cmeta:bio_entity>epidermal growth factor receptor</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<variable name="EGFR" public_interface="out" initial_value="0.1667" units="concentration_units" />
<variable name="delta_EGFR" public_interface="in" units="rate_units" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<apply><diff />
<bvar><ci> time </ci></bvar>
<ci> EGFR </ci>
</apply>
<ci> delta_EGFR </ci>
</apply>
</math>
</component>
<component name="EGF_EGFR" cmeta:id="EGF_EGFR">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGF_EGFR">
<dc:title>epidermal growth factor-receptor complex</dc:title>
<cmeta:bio_entity>
complex of epidermal growth factor and
epidermal growth factor receptor
</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<variable name="EGF_EGFR" public_interface="out" initial_value="0.0" units="concentration_units" />
<variable name="delta1_EGF_EGFR" public_interface="in" units="rate_units" />
<variable name="delta2_EGF_EGFR" public_interface="in" units="rate_units" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<apply><diff />
<bvar><ci> time </ci></bvar>
<ci> EGF_EGFR </ci>
</apply>
<apply><plus />
<ci> delta1_EGF_EGFR </ci>
<ci> delta2_EGF_EGFR </ci>
</apply>
</apply>
</math>
</component>
<component name="EGF_EGFR_Int" cmeta:id="EGF_EGFR_Int">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGF_EGFR_Int">
<dc:title>
internalized epidermal growth factor-receptor complex
</dc:title>
<cmeta:bio_entity>
internalized fraction of complex of epidermal growth factor
and epidermal growth factor receptor
</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<variable name="EGF_EGFR_Int" public_interface="out" initial_value="0.0" units="concentration_units" />
<variable name="delta_EGF_EGFR_Int" public_interface="in" units="rate_units" />
<variable name="time" private_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<apply><diff />
<bvar><ci> time </ci></bvar>
<ci> EGF_EGFR_Int </ci>
</apply>
<ci> delta_EGF_EGFR_Int </ci>
</apply>
</math>
</component>
<!--
This component represents the binding reaction between EGF and EGFR.
-->
<component name="EGF_EGFR_bind_rxn" cmeta:id="EGF_EGFR_bind_rxn">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGF_EGFR_bind_rxn">
<dc:title>EGF-EGFR binding reaction</dc:title>
</rdf:Description>
</rdf:RDF>
<variable name="EGF" public_interface="in" units="concentration_units" />
<variable name="EGFR" public_interface="in" units="concentration_units" />
<variable name="EGF_EGFR" public_interface="in" units="concentration_units" />
<variable name="delta_EGF" public_interface="out" units="rate_units" />
<variable name="delta_EGFR" public_interface="out" units="rate_units" />
<variable name="delta_EGF_EGFR" public_interface="out" units="rate_units" />
<!--
k_forward and k_reverse are the forward and reverse rate constants,
respectively. They are not needed by any other component in the
model, and therefore have no public or private interface
-->
<variable name="k_forward" initial_value="0.000007" units="second_order_rate_constant_units" />
<variable name="k_reverse" initial_value="0.25" units="first_order_rate_constant_units" />
<variable name="r" units="rate_units" />
<!--
This reaction is reversible. The direction attributes on the role
elements are also omitted in this example. The roles of the participants
are all assumed to be for the default direction, i.e.,"forward".
-->
<reaction reversible="yes">
<variable_ref variable="EGF">
<role role="reactant" delta_variable="delta_EGF" stoichiometry="1" />
</variable_ref>
<variable_ref variable="EGFR">
<role role="reactant" delta_variable="delta_EGFR" stoichiometry="1" />
</variable_ref>
<variable_ref variable="EGF_EGFR">
<role role="product" delta_variable="delta_EGF_EGFR" stoichiometry="1" />
</variable_ref>
<variable_ref variable="r">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<ci> r </ci>
<apply><plus />
<apply><minus />
<apply><times />
<ci> k_forward </ci>
<ci> EGF </ci>
<ci> EGFR </ci>
</apply>
</apply>
<apply><times />
<ci> k_reverse </ci>
<ci> EGF_EGFR </ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<!--
This component represents the internalization of the EGF_EGFR
complex.
-->
<component name="EGF_EGFR_internalization" cmeta:id="EGF_EGFR_internalization">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="EGF_EGFR_internalization">
<dc:title>internalization of the EGF-EGFR complex</dc:title>
</rdf:Description>
</rdf:RDF>
<variable name="EGF_EGFR" public_interface="in" units="concentration_units" />
<variable name="EGF_EGFR_Int" public_interface="in" units="concentration_units" />
<variable name="delta_EGF_EGFR" public_interface="out" units="rate_units" />
<variable name="delta_EGF_EGFR_Int" public_interface="out" units="rate_units" />
<!--
Notice that because variable names need only be unique
within a component, and not across the entire model, we can
call the forward and reverse reaction rate constants k_forward
and k_reverse in this component as well as in the
EGF_EGFR_bind_rxn component.
-->
<variable name="k_forward" initial_value="0.002" units="first_order_rate_constant_units" />
<variable name="k_reverse" initial_value="0.00033" units="second_order_rate_constant_units" />
<variable name="r" units="rate_units" />
<reaction reversible="yes">
<variable_ref variable="EGF_EGFR">
<role role="reactant" delta_variable="delta_EGF_EGFR" stoichiometry="1" />
</variable_ref>
<variable_ref variable="EGF_EGFR_Int">
<role role="product" delta_variable="delta_EGF_EGFR_Int" stoichiometry="1" />
</variable_ref>
<variable_ref variable="r">
<role role="rate">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<ci> r </ci>
<apply><plus />
<apply><minus />
<apply><times />
<ci> k_forward </ci>
<ci> EGF_EGFR </ci>
</apply>
</apply>
<apply><times />
<ci> k_reverse </ci>
<ci> EGF_EGFR_Int </ci>
</apply>
</apply>
</apply>
</math>
</role>
</variable_ref>
</reaction>
</component>
<!--
The EGF_subsystem component is a logical component only; i.e., it
does not represent any actual chemical species or reaction. It is
used to encapsulate the portion of the pathway that
results in the EGF-EGFR complex. Note that this is a different use of
encapsulation than is shown in the simple two reaction model with
encapsulation - instead of encapsulating intermediate reactions, we
are encapsulating a complete subsystem. This configuration hides the
components representing the EGF and EGFR species. This means that
these species cannot be used by any other reaction in the model.
If we wanted to make it possible to later add reactions controlling the
production of EGF, for instance, we would need to break this
encapsulation.
-->
<component name="EGF_subsystem" cmeta:id="EGF_subsystem">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="EGF_subsystem">
<dc:title>EGF-EGFR subpathway</dc:title>
<!--
The Annotation metadata has associated metadata: the creator
and the create date. These pieces of metadata refer to the
annotation, not to the model component.
-->
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
The EGF subsystem encompasses the reactions that control
the concentration of the activated EGF-EGFR complex.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nelson</vCard:Family>
<vCard:Given>Melanie</vCard:Given>
</vCard:N>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2000-11-20</dcterms:W3CDTF>
</dcterms:created>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<!--
The subsystem produces the concentration of the EGF-EGFR
complex as output. This variable has a public interface of
"out", which means that it can be connected to other components
in the main pathway. It has a private interface of "in", which
means that the actual value of the concentration must be passed in
to this component from one of the components it encapsulates.
-->
<variable name="EGF_EGFR" public_interface="out" private_interface="in" units="concentration_units" />
<!--
The subsystem requires time to be passed in from the main
network, hence the public interface for the time variable is "in".
The subsystem component then must pass the time variable on
to the components that it encapsulates, and therefore this
variable has a private interface of "out".
-->
<variable name="time" public_interface="in" private_interface="out" units="second" />
</component>
<!--
The group element defines the encapsulation relationship between
the logical EGF_subsystem component and the components that actually
make up that subsystem (the EGF, EGFR, EGF_EGFR, and EGF_EGFR_Int
components)
-->
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="EGF_subsystem">
<component_ref component="EGF" />
<component_ref component="EGFR" />
<component_ref component="EGF_EGFR" />
<component_ref component="EGF_EGFR_Int" />
<component_ref component="EGF_EGFR_bind_rxn" />
<component_ref component="EGF_EGFR_internalization" />
</component_ref>
</group>
<!--
The connections hold the actual mappings between variables declared
in different components. When more than one variable is mapped
between two components, all variable mappings must be listed in
the same connection element (there can only be one connection
between two components). The modeller should NOT rely on matching the names
of the variables in the two components.
-->
<connection>
<map_components component_1="environment" component_2="EGF_subsystem" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="EGF" component_2="EGF_EGFR_bind_rxn" />
<map_variables variable_1="EGF" variable_2="EGF" />
<map_variables variable_1="delta_EGF" variable_2="delta_EGF" />
</connection>
<connection>
<map_components component_1="EGFR" component_2="EGF_EGFR_bind_rxn" />
<map_variables variable_1="EGFR" variable_2="EGFR" />
<map_variables variable_1="delta_EGFR" variable_2="delta_EGFR" />
</connection>
<connection>
<map_components component_1="EGF_EGFR" component_2="EGF_EGFR_bind_rxn" />
<map_variables variable_1="EGF_EGFR" variable_2="EGF_EGFR" />
<map_variables variable_1="delta1_EGF_EGFR" variable_2="delta_EGF_EGFR" />
</connection>
<connection>
<map_components component_1="EGF_EGFR" component_2="EGF_EGFR_internalization" />
<map_variables variable_1="EGF_EGFR" variable_2="EGF_EGFR" />
<map_variables variable_1="delta2_EGF_EGFR" variable_2="delta_EGF_EGFR" />
</connection>
<connection>
<map_components component_1="EGF_EGFR_Int" component_2="EGF_EGFR_internalization" />
<map_variables variable_1="EGF_EGFR_Int" variable_2="EGF_EGFR_Int" />
<map_variables variable_1="delta_EGF_EGFR_Int" variable_2="delta_EGF_EGFR_Int" />
</connection>
<connection>
<map_components component_1="EGF_subsystem" component_2="EGF" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="EGF_subsystem" component_2="EGFR" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="EGF_subsystem" component_2="EGF_EGFR" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="EGF_EGFR" variable_2="EGF_EGFR" />
</connection>
<connection>
<map_components component_1="EGF_subsystem" component_2="EGF_EGFR_Int" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<!--
The rest of the model is "flat"; i.e., there are no additional
encapsulated subsystems.
-->
<component name="SHC" cmeta:id="SHC">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1">
<rdf:Description rdf:about="SHC">
<dc:title>
inactive Src homology 2 domain-containing protein
</dc:title>
<cmeta:bio_entity>
Src homology 2 domain-containing protein
</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<variable name="SHC" public_interface="out" initial_value="0.5" units="concentration_units" />
<variable name="delta_SHC" public_interface="in" units="rate_units" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq />
<apply><diff />
<bvar><ci> time </ci></bvar>
<ci> SHC </ci>
</apply>
<ci> delta_SHC </ci>
</apply>
</math>
</component>
<component name="SHC_active" cmeta:id="SHC_active">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="SHC_active">
<dc:title>
active Src homology 2 domain-containing protein
</dc:title>
<cmeta:bio_entity>
Src homology 2 domain-containing protein
</cmeta:bio_entity>
</rdf:Description>
</rdf:RDF>
<variable name="SHC_active" public_interface="out"