Lloyd Catherine May c.lloyd@auckland.ac.nz The University of Auckland The Bioengineering Institute 2002-03-04 The University of Auckland, Bioengineering Research Group A model of the 2,3-BPG shunt in human erythrocytes. This is the CellML description of Mulquiney, Bubb and Kuchel's mathematical model of the 2,3-BPG shunt in human erythrocytes (1999). Catherine Lloyd Homo Sapiens erythrocyte keyword metabolism 10477268 Mulquiney Peter J Bubb William A Kuchel Philip W Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: in vivo kinetic characterisation of 2,3-bisphosphoglycerate synthase/phosphatase using 13C and 31P NMR 1999-09-15 Biochemical Journal 342 567 580 E free BPGS/P $\frac{d E}{d \mathrm{time}}=\mathrm{delta\_E\_rxn3}+\mathrm{delta\_E\_rxn3a}+\mathrm{delta\_E\_rxn4}+\mathrm{delta\_E\_rxn0}$ A 1,3-BPG $\frac{d A}{d \mathrm{time}}=\mathrm{delta\_A\_rxn0}$ $\frac{d \mathrm{EA}}{d \mathrm{time}}=\mathrm{delta\_EA\_rxn0}+\mathrm{delta\_EA\_rxn1}$ F phosphorylated BPGS/P $\frac{d F}{d \mathrm{time}}=\mathrm{delta\_F\_rxn1}+\mathrm{delta\_F\_rxn2}+\mathrm{delta\_F\_rxn2a}+\mathrm{delta\_F\_rxn5}+\mathrm{delta\_F\_rxn6}$ Pi inorganic phosphate $\frac{d \mathrm{Pi}}{d \mathrm{time}}=\mathrm{delta\_Pi\_rxn2}$ $\frac{d \mathrm{two\_PGly}}{d \mathrm{time}}=\mathrm{delta\_2\_PGly\_rxn2a}$ $\frac{d \mathrm{FPi}}{d \mathrm{time}}=\mathrm{delta\_FPi\_rxn2}+\mathrm{delta\_FPi\_rxn3}$ $\frac{d \mathrm{F2\_PGly}}{d \mathrm{time}}=\mathrm{delta\_F2\_PGly\_rxn2a}+\mathrm{delta\_F2\_PGly\_rxn3a}$ D 2,3-BPG $\frac{d D}{d \mathrm{time}}=\mathrm{delta\_D\_rxn4}$ $\frac{d \mathrm{ED}}{d \mathrm{time}}=\mathrm{delta\_ED\_rxn7}+\mathrm{delta\_ED\_rxn8}+\mathrm{delta\_ED\_rxn4}$ B 3-PGA $\frac{d B}{d \mathrm{time}}=\mathrm{delta\_B\_rxn5}$ $\frac{d \mathrm{FB}}{d \mathrm{time}}=\mathrm{delta\_FB\_rxn5}+\mathrm{delta\_FB\_rxn7}$ C 2-PGA $\frac{d C}{d \mathrm{time}}=\mathrm{delta\_C\_rxn6}$ $\frac{d \mathrm{FC}}{d \mathrm{time}}=\mathrm{delta\_FC\_rxn6}+\mathrm{delta\_FC\_rxn8}$ $\mathrm{rate}=\mathrm{k0}AE+-(\mathrm{k0\_}\mathrm{EA})$ $\mathrm{rate}=\mathrm{k1}\mathrm{EA}$ $\mathrm{rate}=\mathrm{k2}\mathrm{Pi}F+-(\mathrm{k2\_}\mathrm{FPi})$ $\mathrm{rate}=\mathrm{k2a}\mathrm{two\_PGly}F+-(\mathrm{k2a\_}\mathrm{F2\_PGly})$ $\mathrm{rate}=\mathrm{k3}\mathrm{FPi}$ $\mathrm{rate}=\mathrm{k3a}\mathrm{F2\_PGly}$ $\mathrm{rate}=\mathrm{k4}\mathrm{ED}+-(\mathrm{k4\_}DE)$ $\mathrm{rate}=\mathrm{k5}BF+-(\mathrm{k5\_}\mathrm{FB})$ $\mathrm{rate}=\mathrm{k6}CF+-(\mathrm{k6\_}\mathrm{FC})$ $\mathrm{rate}=\mathrm{k7}\mathrm{FB}+-(\mathrm{k7\_}\mathrm{ED})$ $\mathrm{rate}=\mathrm{k8}\mathrm{FC}+-(\mathrm{k8\_}\mathrm{ED})$